Biolegend, 321809, Purified anti-human OSMR Antibody, 100μg

Oncostatin M receptor (OSMR), also known as IL-31 receptor subunit beta, is a member of the IL-6 receptor family. It is expressed in bone marrow, endothelium, liver, lung and skin tissues. OSMR forms the type II OSM receptor complex when paired with interleukin 6 signal transducer (gp130) and forms the IL-31 receptor when complexed with interleukin 31 receptor A (IL31RA). The binding of OSM to either of these receptors triggers activation of the JAK-STAT signaling pathway.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human OSMR protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone S22005D does not affect the binding of clone S22005H on target cells.
RRID: AB_3720538 (BioLegend Cat. No. 321809)
Structure: Transmembrane immunoglobulin-like glycoprotein, 130 kD
Distribution: Hepatocytes, mesothelial cells, glial cells and epithelial cells
Function: Ligand binding, signal transduction
Interaction: gp130, IL-31RA
Ligand/Receptor: IL-31, OSM
Cell Type: Epithelial cells, Macrophages, Mesenchymal cells, Monocytes
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: Mosley B, et al. 1996. J Biol Chem. 271:32635. Auguste P, et al. 1997. J Biol Chem. 272:15760. Hermanns HM, et al. 1999. J. Immunol. 163:6651.
Gene ID: 9180
UniProt: View information about OSMR on UniProt.org
Clone: S22005D
Regulatory Status: RUO
Other Names: OSMRβ, IL-31R
Isotype: Mouse IgG1, κ