Biolegend, 327206, PE anti-human Delta Opioid Receptor Antibody, 100tests

Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, µ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: HEK-293/human Delta Opioid Receptor
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2298899 (BioLegend Cat. No. 327206)
Structure: Seven transmembrane G-protein coupled receptor
Distribution: Brain cortical area, including olfactory bulb, hippocampus, and amygdale, nucleus accumbens
Function: Inhibit cAMP production, increase phosphodiesterase activity, control anxiety, depression, and pain
Ligand/Receptor: enkephalins
Biology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family: GPCR
Antigen References: 1. Simonin F, et al. 1994. Mol. Pharmacol. 46:1015. 2. Befort K, et al. 1994. Genomics 20:143. 3. Bzdega T, et al. 1993. Proc. Nat. Acad. Sci. 90:9305. 4. Jordan BA. And LA Devi. 1999. Nature 399:697. 5. Xue K, et al. 2002. Am. J. Med. Genet. 11:45.
Gene ID: 4985
UniProt: View information about Delta Opioid Receptor on UniProt.org
Clone: DOR7D2A4
Regulatory Status: RUO
Other Names: OPRD, DOR, hDOR
Isotype: Mouse IgG2b, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.