Biolegend, 332705, APC anti-human CD305 Recombinant Antibody, 25tests

CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.
25tests
Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Application Notes: Clone QA19A19 can completely block the binding of clone NKTA255 on target cells.
RRID: AB_3683349 (BioLegend Cat. No. 332705) AB_3683349 (BioLegend Cat. No. 332706)
Structure: 40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
Distribution: Expressed on epithelial and mesothelial cells
Function: NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
Interaction: Human
Ligand/Receptor: Collagens
Cell Type: B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
Biology Area: Immunology, Inhibitory Molecules, Innate Immunity
Molecular Family: CD Molecules
Antigen References: Meyaard L, et al. 2008. J Leukoc Biol. 83:799-803. Lebbink RJ, et al. 2006. J Exp Med. 203:1419-25.
Gene ID: 3903
UniProt: View information about CD305 on UniProt.org
Clone: QA19A19
Regulatory Status: RUO
Other Names: LAIR-1 (Leukocyte-associated Ig-like receptor 1)
Isotype: Mouse IgG1, κ