Biolegend, 341212, PE/Cyanine7 anti-human CD160 Antibody, 100tests

CD160 is a 27 kD GPI-anchored glycoprotein also known as BY55, NK1, and NK28. A member the Ig superfamily, CD160 exists as a disulfide-bond multimer, expressed on the surface of a subpopulation of NK cells, γ/δ T cells, subset of CD8+ T cells, and intestinal intraepithelial lymphocytes (IEL). CD160 plays costimulatory roles through binding to classical and nonclassical MHC-I molecules.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References(PubMed link indicates BioLegend citation): Anumanthan A, et al. 1998. J. Immunol. 161:2780. Maiza H, et al. 1993. J. Exp. Med. 178:1121.
Product Citations: Li X, et al. 2019. Front Oncol. 1.115277778. PubMed Maas RJ, et al. 2020. Oncoimmunology. 9:1843247. PubMed Kong Y, et al. 2016. Clin Cancer Res. 22: 3057 - 3066. PubMed Collins DR, et al. 2021. Immunity. 54:2372. PubMed Kong Y, et al. 2015. Blood Cancer J. 5: 330. PubMed
RRID: AB_2562875 (BioLegend Cat. No. 341211) AB_2562876 (BioLegend Cat. No. 341212)
Structure: 27 kD GPI-anchored glycoprotein, Ig superfamily
Distribution: Subpopulation of NK cells, γ/δ T cells, subset of CD8+ T cells, and intestinal intraepithelial lymphocytes (IEL)
Function: Costimulation
Ligand/Receptor: Classical and nonclassical MHC-I molecules
Cell Type: NK cells, T cells
Biology Area: Costimulatory Molecules, Immunology
Molecular Family: CD Molecules
Antigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication. 2. Merino J, et al. 2007. Clin. Exp. Immunol. 149:87. 3. Barakonyi A, et al. 2004. J. Immunol. 173:5349.
Gene ID: 11126
UniProt: View information about CD160 on UniProt.org
Clone: BY55
Regulatory Status: RUO
Other Names: BY55, NK1, NK28
Isotype: Mouse IgM, κ