Biolegend, 355802, Purified anti-human LAMP5 Antibody, 100μg

Lysosome-associated membrane protein 5 (LAMP5), also known as BAD-LAMP, UNC-43, and C20orf103, is a new member of LAMP family.  It is a transmembrane glycosylated protein localized in the ER-Golgi intermediate compartment (ERGIC). LAMP5 shares sequence and structural homology with the canonical LAMP1 (CD107a) and LAMP2 (CD107b) molecules, harbors an endosomal addressing signal within its cytoplasmic tail, and contains several conserved cysteine residues that allow for the formation of particular structural loops known as LAMP folds. In mice, LAMP5 is expressed in postnatal cortical neurons of particular layers, where it is enriched in defined zones along neuronal projections. Human LAMP5, like its murine homolog, is principally expressed in brain; it is also specifically found in primary CD303 (BDCA-2)-positive pDCs (plasmacytoid dendritic cells).  It represents a novel marker of human primary and transformed pDCs.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Cells expressing C20orf103.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining using our nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Additional Product Notes: View more applications data using a previous version of this product in our Scientific Poster Library.
RRID: AB_2561712 (BioLegend Cat. No. 355802)
Structure: A transmembrane glycosylated protein
Distribution: pDCs
Cell Type: Dendritic cells
Biology Area: Immunology
Antigen References: 1. Defays A, et al. 2011. Blood 118:609. 2. David A, et al. 2007. J. Cell. Sci. 120:353.
Gene ID: 24141
UniProt: View information about LAMP5 on UniProt.org
Clone: 124-40B
Regulatory Status: RUO
Other Names: UNC-43, BADLAMP, BAD-LAMP, C20orf103
Isotype: Mouse IgG1, κ