Biolegend, 364504, Alexa Fluor® 594 anti-human LYPD3 Antibody, 100μg

C4.4A, also known as Ly6/PLAUR domain containing 3 (LYPD-3), is a GPI-linked protein with structural similarity to the urokinase-type plasminogen activator receptor (uPAR). C4.4A is also expressed in the placenta, skin and urothelium and can be found in suprabrasal layers of stratified squamous epithelium and is upregulated on migrating keratinocytes during wound healing. Human C4.4A mRNA has been detected in cancer cell lines, including melanoma, breast, bladder, and renal cell carcinoma, as well as in tumor tissue samples from malignant melanoma, colorectal cancer (CRC), breast cancer, lung carcinoma, and urothelial tumors. Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
RRID: AB_3097220 (BioLegend Cat. No. 364503) AB_3097220 (BioLegend Cat. No. 364504)
Distribution: Placenta, skin, urothelium, keratinocytes
Function: Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells
Interaction: LGALS3 (By similarity). AGR2 and AGR3
Ligand/Receptor: Laminin-1 and laminin-5
Biology Area: Cell Adhesion
Molecular Family: Adhesion Molecules
Antigen References: Smith BA, et al. 2001. Cancer Res. 61:1678-85. Würfle J, et al. 2001. Gene. 262:35-41.
Gene ID: 27076
UniProt: View information about LYPD3 on UniProt.org
Clone: 11A1
Regulatory Status: RUO
Other Names: C4.4A, GPI-Anchored Metastasis-Associated Protein C4.4A Homolog, LY6/PLAUR Domain Containing 3
Isotype: Mouse IgG2b, κ