Biolegend, 365002, Purified anti-human CD66c Antibody, 100μg

CD66c, also known as CEACAM6, is one of the splice variants of CD66. It is expressed on endothelial, epithelial cells, neutrophils, monocytes, and myeloma and cancer cells, such as B-cell acute lymphoblastic lymphomas. CD66 expression level can be induced on T cells, B cells, and CD16-negative NK cells. Like the other CD66 splice variants, CD66c is involved in cell adhesion and growth, neutrophil activation, and signaling. It plays a role in hemophilic and heterophilic adhesion.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2904392 (BioLegend Cat. No. 365002)
Structure: Member of the CEA (carcinoembryonic antigen) family of the Ig superfamily
Distribution: Granulocytes, epithelial cells
Function: Homophilic and heterophilic adhesion
Ligand/Receptor: CD66a-e, CD62E and Galectins
Cell Type: Epithelial cells, Granulocytes
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss. A John Wiley & Sons Inc. Publication
Gene ID: 4680
UniProt: View information about CD66c on UniProt.org
Clone: 1D4/CD66c
Regulatory Status: RUO
Other Names: CEACAM 6
Isotype: Mouse IgG3, κ