Biolegend, 371402, Purified anti-human CD92 Antibody, 100μg

CD92, also known as CDW92 and CTL1, is a 70kD choline transporter-like transmembrane protein. CD92 is important for transport of choline across the membrane for synthesis of cell membrane components and the neurotransmitter, acetylcholine. CD92 is primarily expressed on monocytes and neutrophils, but can also be found on other myeloid and T-cell subsets. Ionomycin or calcium ionophore mediates the maturation of monocytic dendritic cells causing down-regulation of CD92 but treatment with IL-10 causes re-expression.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: MV4-11
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application References(PubMed link indicates BioLegend citation): Wille S, et al. 2001. J. Immunol. 167:5795.
RRID: AB_2572178 (BioLegend Cat. No. 371402)
Structure: 70kD choline transporter-like transmembrane protein.
Distribution: Monocytes, neutrophils, and certain groups of T-cells.
Function: Transport of choline through the cell membrane.
Interaction: Choline.
Cell Type: Monocytes, Neutrophils, T cells
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Schenkel LC, et al. 2015. FASEB J. 29:1663. 2. Yamada T, et al. 2011. Neurochem. Int. 58:354. 3. Fullerton MD, et al. 2006. Am. J. Physiol. Cell Physiol. 290:C1230.
Gene ID: 23466
UniProt: View information about CD92 on UniProt.org
Clone: VIM15b
Regulatory Status: RUO
Workshop: HCDM listed
Other Names: CD92, CDw92, CTL1, SLC44A1
Isotype: Mouse IgG2b, κ