Biolegend, 374002, Purified anti-human CD309 (VEGFR2) Antibody, 100μg

CD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant Human VEGFR2-Fc Chimera
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2687130 (BioLegend Cat. No. 374002)
Structure: Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1/PDGF receptor family
Distribution: Endothelial cells, embryonic tissues
Function: VEGFR2 regulates angiogenesis as well as vascular development and permeability
Interaction: VEGF-A, SHC2, NPR1, NCK1
Ligand/Receptor: VEGF-A, VEGF-C, and VEGF-D splice isoforms
Cell Type: Endothelial cells
Biology Area: Angiogenesis, Cell Biology, Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. DiSalvo J, et al. 1995. J. Biol. Chem. 270:7717. 2. McColl BK, et al. 2003. J. Exp. Med. 198:863. 3. Albuquerque RJ, et al. 2009. Nat. Med. 15:1023. 4. Guangqi E, et al. 2012. J. Biol. Chem. 287:3029. 5. Koch S, and Claesson-Welsh 2012. Cold Spring Harb Perspect Med 2:a006502. 6. Munaut C, et al. 2012. Plos One 7:e33475. 7. Wehland M, et al. 2013. Int. J. Mol. Sci. 14:9338.
Gene ID: 3791
UniProt: View information about CD309 on UniProt.org
Clone: A16085I
Regulatory Status: RUO
Other Names: VEGFR2, KDR
Isotype: Mouse IgG2b, κ