Biolegend, 377119, Purified anti-human EMR1 Antibody, 100μg

EGF-like module-containing mucin-like hormone receptor-like 1, also known as F4/80, is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. Unlike its murine counterpart, which is widely used as a murine macrophage marker, the expression of human EMR1 is specific to eosinophils. Due to the restricted expression of EMR1, EMR1 is used as a therapeutic target for eosinophilic disorders.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Human ADGRE1/EMR1 (a.a. 21-599)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone W23100E does block the binding of clone QA19A76 on target cells.
Structure: Seven transmembrane regions six EGF-like modules
Distribution: Eosinophils
Antigen References: Hamman J, et al. 2007. Eur J Immuno. 37:5797-2802 Akter R, et al. 2024. Int J Mol Sci. 25:4388.
Gene ID: 2015
UniProt: View information about EMR1 on UniProt.org
Clone: W23100E
Regulatory Status: RUO
Other Names: Adhesion G protein-coupled receptor E1 (ADGRE1), EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EMR1 hormone receptor, TM7LN3
Isotype: Rat IgG2a, κ