Biolegend, 378902, Purified anti-human TSPAN8 Antibody, 100μg

Tetraspanin 8 (TSPAN8) is a member of the transmembrane IV superfamily.  It is a cell surface protein with four hydrophobic domains. Tetraspanins are constitutive components of exosomes and are involved in adhesion, motility, matrix modulation and cell fusion. TSPAN8 mediates signal transduction events that regulate cell development, activation, growth, and motility. It is expressed in gastric, colon, rectal, and pancreatic carcinomas.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: huTSPAN8 transfectant
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2910444 (BioLegend Cat. No. 378902)
Structure: Multi-pass membrane protein
Distribution: Cell membrane, lysosomes
Function: Tyrosine-based internalization, recruitment into endosomes
Interaction: LIPR1, MEP1B, STX1-2, TIM23, S38A7
Biology Area: Immunology
Antigen References: Szala S, et al. 1990. Proc Natl Acad Sci USA. 87:6833-7. Rana S, et al. 2011. Int J Biochem Cell Biol. 43:106-19. Nazarenko I, et al. 2010. Cancer Res. 70:1668-78. Berthier-Vergnes O, et al. 2011. Br J Cancer. 104:155-68.
Gene ID: 7103
UniProt: View information about TSPAN8 on UniProt.org
Clone: S20010A
Regulatory Status: RUO
Other Names: Tetraspanin-8
Isotype: Mouse IgG1, κ