Biolegend, 378903, PE anti-human TSPAN8 Antibody, 25tests

Tetraspanin 8 (TSPAN8) is a member of the transmembrane IV superfamily.  It is a cell surface protein with four hydrophobic domains. Tetraspanins are constitutive components of exosomes and are involved in adhesion, motility, matrix modulation and cell fusion. TSPAN8 mediates signal transduction events that regulate cell development, activation, growth, and motility. It is expressed in gastric, colon, rectal, and pancreatic carcinomas.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: huTSPAN8 transfectant
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2941553 (BioLegend Cat. No. 378903) AB_2941553 (BioLegend Cat. No. 378904)
Structure: Multi-pass membrane protein
Distribution: Cell membrane, lysosomes
Function: Tyrosine-based internalization, recruitment into endosomes
Interaction: LIPR1, MEP1B, STX1-2, TIM23, S38A7
Biology Area: Immunology
Antigen References: Szala S, et al. 1990. Proc Natl Acad Sci USA. 87:6833-7. Rana S, et al. 2011. Int J Biochem Cell Biol. 43:106-19. Nazarenko I, et al. 2010. Cancer Res. 70:1668-78. Berthier-Vergnes O, et al. 2011. Br J Cancer. 104:155-68.
Gene ID: 7103
UniProt: View information about TSPAN8 on UniProt.org
Clone: S20010A
Regulatory Status: RUO
Other Names: Tetraspanin-8
Isotype: Mouse IgG1, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.