Biolegend, 379302, Purified anti-human CD266 Antibody, 100μg

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2910445 (BioLegend Cat. No. 379302)
Structure: Transmembrane TNF superfamily receptor, contains no death domain, 14 kD
Distribution: Widely expressed in heart, placenta, lung, muscle, kidney, pancreas, and HUVEC
Function: Binds to TWEAK (CD255), thought to play a role in cell death and inflammation
Ligand/Receptor: TWEAK (CD255); interacts with cytoplasmic proteins TRAF1, 2, and 3
Antigen References: Feng SL, et al. 2000. Am J Pathanol. 156:1253-61. Meighan-Mantha RL, et al. 1999. J Biol Chem. 274:33166-79. Nakayama M, et al. 2003. J Immunol. 170:341-8. Lynch CN, et al. 1999. J Biol Chem. 274:8455-9.
Gene ID: 51330
UniProt: View information about CD266 on UniProt.org
Clone: A19192A
Regulatory Status: RUO
Other Names: Fibroblast growth factor-inducible 14 kD protein (Fn14), TWEAK receptor, TNFRSF12A
Isotype: Mouse IgG2b, κ