Biolegend, 385904, APC anti-human IL-17A Recombinant Antibody, 100tests

IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A is the signature cytokine of Th17 subpopulation of CD4+ T cells. Neutrophils are also a major source of IL-17A. IL-17A can elicit multiple biological activities on a variety of cells. For instance, IL-17A can induce IL-6, IL-8, G-CSF, and PGE2 production from epithelial cells, endothelial cells, or fibroblast. IL-17A also further regulates neutrophil functions. Human IL-17A shares 63%, 63% and 72% amino acid sequence similarity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS) respectively.
100tests
Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Application Notes: Clone QA18A46 can completely block the binding of clone BL168 on target cells.
RRID: AB_3068058 (BioLegend Cat. No. 385903) AB_3068058 (BioLegend Cat. No. 385904)
Structure: ~15 kD cytokine
Distribution: Activated T cells, neutrophils
Function: Proinflammatory cytokine
Ligand/Receptor: IL-17A receptor
Cell Type: Lymphocytes, Neutrophils, T cells, Th17
Biology Area: Adaptive Immunity, Immunology, Innate Immunity
Molecular Family: Cytokines/Chemokines
Antigen References: Spriggs MK. 1997. J Clin Immunol. 17:366-9. Kawaguchi M, et al. 2004. J Allergy Clin Immunol. 114:1265-73. Furuzawa-Carballeda J, et al. 2007. Autoimmun Rev. 6:169-75.
Gene ID: 3605
UniProt: View information about IL-17A on UniProt.org
Clone: QA18A46
Regulatory Status: RUO
Other Names: Interluekin 17A, IL-17, CTLA8
Isotype: Mouse IgG1, κ