Biolegend, 392803, Alexa Fluor® 594 anti-human CD66d/e Antibody, 25μg

The 308/3-3 mAb reacts with an antigen epitope shared by CD66d and e. CD66d/e are members of the CEA (carcinoembryonic antigen) family of the Ig superfamily. CD66 plays a role in hemophilic and heterophilic adhesion. CD66d is a major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neisseria , Moraxella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. CD66e molecule is also called CEA or CEACAM5, and is primarily found on epithelial cells. CD66e binds to CD66a, c and e.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant soluble human CEACAM3-Fc produced in HEK293 cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
RRID: AB_2734446 (BioLegend Cat. No. 392803)
Structure: Ig superfamily, CEA antigen group, GPI-linked glycoprotein
Distribution: Granulocytes
Function: Cell adhesion, neutrophil activation
Interaction: CEACAM1, 5,6, SRC and ZPLD1.
Ligand/Receptor: CD66d: CEACAM1, SRC.CD66e: CEACAM1, 5, 6.
Cell Type: Granulocytes
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Chen T, et al. 2001. J Biol Chem. 276:17413 Wang Z, et al. 2016. Mol Clin Oncol. 5:731 Swords DS, et al. 2016. Onco Targets Ther. 9:7459
Gene ID: 1084
UniProt: View information about CD66d CD66e on UniProt.org
Clone: 308/3-3
Regulatory Status: RUO
Other Names: CEACAM3, CGM1, CEACAM5, CEA
Isotype: Mouse IgG1, κ