Biolegend, 398802, Purified anti-human CD56 (NCAM) Recombinant Antibody, 100μg

CD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.
100μg
Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2832780 (BioLegend Cat. No. 398802)
Structure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein
Distribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias
Function: Adhesion
Ligand/Receptor: Heparin sulfate
Cell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, T cells
Biology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Rosental B, et al. 2011. J Immunol. 187:5693. PubMed Correia DV, et al. 2011. Blood. 118:992. PubMed Schlecker E, et al. 2014. Cancer Res. 74:3429. PubMed Snyder JM, et al. 2014. PLoS One. 9:e107257. PubMed Siebert N, et al. 2014. PLoS One. 9:e107692. PubMed Rider P, et al. 2015. J Immunol. 195:1705-12. PubMed Davis ZB, et al. 2011. J Vis Exp. 49: 2668. PubMed Robin JD, et al. 2015. J Vis Exp. 95: 52307. PubMed Ames E, et al. 2015. J Immunol. 195: 4010-9. PubMed Laroni A, et al. 2016. J Autoimmun. 72:8-18. PubMed Pachnio A, et al. 2016. PLoS Pathog. 12:e1005832. PubMed Wouters K, et al. 2017. Sci Rep. 7:42665. PubMed
Gene ID: 4684
UniProt: View information about CD56 on UniProt.org
Clone: QA18A21
Regulatory Status: RUO
Other Names: Leu-19, NKH1
Isotype: Mouse IgG1, κ