Biolegend, 399105, APC anti-human CD339 (Jagged 1) Antibody, 25tests

CD339, also known as Jagged 1, is a 135 kDa type 1 transmembrane protein with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. Jagged 1 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Some studies suggest Jagged 1 is also involved in Th2 polarization and Treg induction.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Human Jagged-transfected RBL1 cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Product Citations: Sun S, et al. 2024. Nat Commun. 7698:15. PubMed
RRID: AB_2894539 (BioLegend Cat. No. 399105) AB_2894539 (BioLegend Cat. No. 399106)
Structure: A 135 kD type 1 transmembrane protein with 1 DSL domain, 15 EGF-like domain and 1 cysteine-rich region.
Distribution: Macrophages, subset of dendritic cells, astrocytes, stromal and epithelial cells.
Function: Regulate cell fate decisions in tissues, neurogenesis, Th2 polarization, and Treg induction
Ligand/Receptor: Notch
Cell Type: Astrocytes, Dendritic cells, Epithelial cells, Macrophages, Monocytes
Biology Area: Cardiovascular Biology, Immunology, Neuroscience
Molecular Family: CD Molecules
Antigen References: Oda T, et al. 1997. Nat. Genet. 16:235. Li L, et al. 1997. Nat. Genet. 16:243. Guarnaccia C, et al. 2004. FEBS Letters. 574:156. High FA, et al. 2008. Proc. Natl. Acad. Sci. 105:1955. Kopan R and Ilagan MX. 2009. Cell. 137:216. Reedijk M, et al. 2005. Cancer Res. 65:8530. Grochowski CM, et al. 2016. Gene. 576:381. Hofmann JJ, et al. 2012. Development. 139:4449.
Gene ID: 182
UniProt: View information about CD339 on UniProt.org
Clone: W16199B
Regulatory Status: RUO
Other Names: JAG1, Jag-1, Jagged1, Jagged-1
Isotype: Rat IgG2a, κ