Biolegend, 449804, ELISA MAX™ Deluxe Set Human Phospho-EGFR (Tyr845), 5plates

EGFR (Epidermal Growth Factor Receptor) is a member of the ErbB family of cell surface receptors. It is an oncoprotein which has been found to have increased expression and activity in multiple cancer types. However, low activity of EGFR can result in degenerative diseases such as Alzheimer’s disease. EGFR signaling pathway starts when it binds to the ligand EGF, resulting in receptor dimerization, transphosphorylation of the C-terminal tails, and propagation of the signal downstream. Each phosphorylation site can serve as a docking site for different proteins of different signaling pathways. Phosphorylation of tyrosine 845 is associated with regulation of receptor function and tumor progression via c-Src in a Zn2+-dependent manner. BioLegend’s ELISA MAX™ Deluxe Set contains the components necessary for the accurate quantification of natural and recombinant human Phospho-EGFR (Tyr845). The set is designed for cost-effective and accurate quantification of human Phospho-EGFR (Tyr845) in cell and tissue lysates. BioLegend’s ELISA MAX™ Deluxe Sets are sensitive, accurate, and robust.
5plates
Verified Reactivity: Human
Application: ELISA
Sensitivity: 0.064 ± 0.036 ng/mL
Standard Range: 0.16 - 10 ng/mL
Cell Type: Epithelial cells
Biology Area: Cancer Biomarkers, Cell Biology, Immuno-Oncology, Immunology, Signal Transduction
Molecular Family: Phospho-Proteins, Protein Kinases/Phosphatase
Gene ID: NA
UniProt: View information about EGFR Tyr845 on UniProt.org
Regulatory Status: RUO
Other Names: Human Phospho EGFR (Y 845), Human EGFR (pTyr845), Human EGFR (pY845)
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.