Biolegend, 600952, Purified anti-Thrombospondin 1 Antibody, 100μg

Thrombospondin 1 (THBS1) is a member of the thrombospondin family, a group of matricellular proteins that comprise a part of the extracellular matrix. Originally discovered in platelets, THBS1 mediates cell-cell interactions interacting with numerous ligands including heparin, integrins, CD36, and CD47. Through this activity, THBS1 regulates cell adhesion, motility and growth. THBS1 has been implicated in the activity of various cancers, by mediating angiogenesis and tumor cell invasion, and also plays a role in heart disease, fibrosis, and eye health.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant N-terminal fragment of THBS1
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2910473 (BioLegend Cat. No. 600951) AB_2910473 (BioLegend Cat. No. 600952)
Structure: THBS1 is a 1,170 amino acid protein with a predicted molecular weight of 130 kD.
Distribution: Secreted protein expressed by multiple cell types including platelets, smooth muscle cells, fibroblasts, and granulocytes
Function: TGF-β signaling, angiogenesis
Ligand/Receptor: Heparin, HSPG, sulfatides, versican, calreticulin, integrins, MMPs, TGF-β, CD36, CD47, CD148
Cell Type: Endothelial cells
Biology Area: Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Motility/Cytoskeleton/Structure
Molecular Family: Adhesion Molecules
Antigen References: Zhang K, et al. 2020. Int J Mol Med. 45:1275-1293. Wang P, et al. 2020. Curr Pharm Des. 26:2116-2136.
Gene ID: 7057
UniProt: View information about Thrombospondin 1 on UniProt.org
Clone: W20027B
Regulatory Status: RUO
Other Names: Glycoprotein G, THBS-1
Isotype: Rat IgG2a, κ