Biolegend, 619852, Purified anti-STAT2 Phospho (Tyr690) Antibody, 100μg

STAT2 is a member of the STAT family of transcription factors that is phosphorylated by receptor associated kinases in response to cytokines and growth factors. After activation, STAT2 forms heterodimers with STAT1. Once it is activated, STAT1 and STAT2 dimerize and are translocated to the nucleus to act as a transcription factor. STAT2 is an important mediator of type I interferon signaling; thus, after type-I IFN binds to the receptor, JAK kinases phosphorylate STAT2 and STAT1. This leads to their dimerization and, together with IRF9/ISGF3G, form the ISGF3 transcription factor. Type-I IFN /STAT2 signaling is important in innate immunity antiviral responses. Additionally, STAT2 is a regulator of mitochondrial fission by modulating phosphorylation of DNM1L. Diseases associated with STAT2 are the Immunodeficiency 44 and Pseudo-Torch Syndrome 3.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Synthetic peptide from human STAT2 phosphorylated at Tyr690
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3068194 (BioLegend Cat. No. 619851) AB_3068194 (BioLegend Cat. No. 619852)
Structure: STAT2 is an 851 amino acids length protein with a predicted molecular weight of 97.9 kD. STAT2 contains a SH2 domain
Distribution: Cytoplasm/Nucleus
Function: Transcription factor, activation in depending of phosphorylation
Interaction: Interacts with IRF9/ISGF3G to form ISGF3 transcription factor complex
Biology Area: Cell Biology, Immunology, Innate Immunity, Transcription Factors
Molecular Family: Innate Immune Signaling, Phospho-Proteins
Antigen References: Ho J, et al. 2016. PLoS Biol. 14:e2000117. Fu X, et al. 1992. PNAS. 89:7840-3. Yu w, et al. 2020. Redox Biol. 37:101761 Lee CJ, et al. 2020. Exp Mol Med. 52:1526-1536.
Gene ID: 6773
UniProt: View information about STAT2 on UniProt.org
Clone: W21151B
Regulatory Status: RUO
Other Names: Signal transducer and activator of transcription 2, STAT113, Interferon alpha induced transcriptional activator, p113
Isotype: Mouse IgG2a, κ