Biolegend, 690702, Purified anti-SH2D1A (SAP) Antibody, 100μg

SH2D1A, also known as SAP, is a small adaptor protein which plays a major role in the bidirectional stimulation of T and B cells. SH2D1A is predominantly expressed in T cells and NK cells, and functions to regulate signal transduction pathways downstream of the SLAM family of surface receptors. The SH2D1A gene is frequently mutated in patients with X-linked lymphoproliferative disease. Malfunction of the SLAM-SAP pathway results in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents.
100μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Full length purified human SH2D1A.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2629824 (BioLegend Cat. No. 690702)
Structure: 128 amino acids with a characteristic of SH2 domain. The predicted molecular weight is approximately 14kD.
Distribution: T cells, NK cells and monocytes.
Function: Stimulation of T and B cells.
Interaction: SLAM family, SH2D1B, and FYN.
Ligand/Receptor: SLAM family; SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7.
Cell Type: T cells, NK cells, Monocytes
Biology Area: Cell Biology, Immunology, Signal Transduction
Antigen References: 1. Tangye SG. 2014. J. Clin. Immunol. 34:772.2. Yang X, et al. 2012. Pediatr. Int. 54:447.3. Ma CS, Deenick EK. 2011. Ann. N Y Acad. Sci. 1217:32-44.4. Detre C, et al. 2010. Semin. Immunopathol. 32:157.5. Vilar ML, et al. 2011. Braz. J. Med. Biol. Res. 44:276.
Gene ID: 4068
UniProt: View information about SH2D1A on UniProt.org
Clone: 1A9
Regulatory Status: RUO
Other Names: SH2 Domain Containing 1A, SAP, T-Cell Signal Transduction Molecule SAP, SLAM-Associated Protein, T Cell Signal Transduction Molecule SAP, MTCP1, XLPD
Isotype: Rat IgG2a, κ