Biolegend, 693202, Purified anti-ETS2 Antibody, 100μg

ETS erythroblastosis virus E26 oncogene homologue 2 (ETS2), also known as ETS2IT1, is a member of the ETS transcription factor family. ETS2 contains one conserved winged helix-turn-helix ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T. ETS2 has been found to be an evolutionary conserved proto-oncogene and is a downstream regulator of the Ras/Raf/MAPK pathway. ETS2 participates in the regulation of the genes involved in stem cell development, cell senescence, cell death, apoptosis, and tumorigenesis. Defects in ETS2 gene have been associated with choriocarcinoma and Down syndrome.
100μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Partial human ETS2 recombinant protein (1-250 a.a.) expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2632833 (BioLegend Cat. No. 693202)
Structure: 469 amino acids with a predicted molecular weight of 53 kD. Contains an ETS DNA-binding domain and a PNT (pointed) domain.
Distribution: Nucleus.
Function: ETS2 is a transcription factor downstream of the Ras/Raf/MAPK pathway. ETS2 is a proto-oncogene involved in stem cell development, cell senescence, cell death, apoptosis, and tumorigenesis.
Interaction: Interacts with CDK10, RFWD2, TWIST1, and TWIST2.
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Transcription Factors
Antigen References: 1. Carrero ZI, et al. 2016. Oncotarget. 7:12554.2. Donnison M, et al. 2015. Dev. Biol. 397:77.3. Guen VJ, et al. 2013. Proc. Natl. Acad. Sci. USA 110:19525.4. Polydorou C, Georgiades P. 2013. Nat. Commun. 4:1658.5. Do PM, et al. 2012. Genes Dev. 26:830.6. Zabuawala T, et al. 2010. Cancer Res. 70:1323.
Gene ID: 2114
UniProt: View information about ETS2 on UniProt.org
Clone: W15163A
Regulatory Status: RUO
Other Names: v-ets avian erythroblastosis virus E26 oncogene homolog 2, Protein C-ets-2, ETS proto-oncogene 2, ETS2IT1
Isotype: Mouse IgG1, κ