Biolegend, 695602, Purified anti-BACH2 Antibody, 100μg

BTB and CNC Homolog 2 (BACH2) is a transcription factor of the basic leucine zipper family. BACH2 participates in the regulation of both innate and adaptive immune responses. In B cells, BACH2 plays critical roles in somatic hypermutation, class-switch recombination, memory B cell formation, and repression of myeloid genes. In T cells, BACH2 promotes the development of Foxp3+ regulatory T cells and memory T cells. Bach2 is required for the maintenance of naive CD4 T cells by suppressing effector T cell differentiation. BACH2 is also required for the maturation and function of alveolar macrophages. Defects in BACH2 gene are associated with autoimmune and allergic diseases, such as asthma, type 1 diabetes, celiac disease, rheumatoid arthritis, and generalized vitiligo.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human BACH2 recombinant protein (513-841 a.a.) expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2650879 (BioLegend Cat. No. 695602)
Structure: 841 amino acids with a predicted molecular weight of 92.5 kD. Contains a N-terminal BTB/POZ domain for protein-protein interaction and a C-terminal bZIP domain for DNA binding.
Distribution: Nucleus and cytoplasm.
Function: BACH2 is a transcription factor involved in the development and differentiation of both B and T cells.
Interaction: Forms homodimers or heterodimers with Maf-related transcription factors.
Cell Type: B cells, Tregs
Biology Area: Cell Biology, Immunology, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Kuwahara M, et al. 2016. Nat. Commun. 7:12596. 2. Sidwell T, et al. 2016. Nat. Immunol. 17:744. 3. Roychoudhuri R, et al. 2016. Nat. Immunol. 17:851. 4. Itoh-Nakadai A, et al. 2014. Nat. Immunol. 15:1171. 5. Kuwahara M, et al. 2014. Nat. Commun. 5:3555. 6. Kim EH, et al. 2014. J. Immunol. 192:985.
Gene ID: 60468
UniProt: View information about BACH2 on UniProt.org
Clone: 16B10B53
Regulatory Status: RUO
Other Names: BTB and CNC homolog 2, Transcription regulator protein BACH2,
Isotype: Mouse IgG1, κ