Biolegend, 801213, Purified anti-Tubulin β 3 (TUBB3) Antibody (Previously Covance catalog# MMS-435P), 25microl

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.
25microl
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This antibody was raised against microtubules derived from rat brain.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Previous lots (B465167 and prior) of this product may have been formulated in Phosphate-buffered solution + 0.03% Thimerosal. For further information please contact BioLegend Technical Support or Customer Service.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 1.0 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application: IHC-P - Quality tested WB, ICC - Verified FC - Reported in the literature, not verified in house SB - Community verified
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, Western blotting8, and spatial biology (IBEX)9,10. This antibody is well characterized and highly reactive to neuron specific Class III ß-tubulin (ßIII). TUJ1 does not identify ß-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.
Additional Product Notes: This product has been verified for IHC-F (Immunohistochemistry - frozen tissue sections) on the NanoString GeoMx® Digital Spatial Profiler. The GeoMx® enables researchers to perform spatial analysis of protein and RNA targets in FFPE and fresh frozen human and mouse samples. For more information about our spatial biology products and the GeoMx® platform, please visit our spatial biology page.
Application References(PubMed link indicates BioLegend citation): Nishimura K, et al. 2017. PLoS One. 12(1): e0170568. (ICC) Jongbloets J, et al. 2017. Nat Commun. 8: 14666. (ICC) PubMed Liu W.J, et al. 2015. Eur J Histochem. 59(1): 2464. (ICC) PubMed Chintalapudi SR, et al. 2016. Front Aging Neursci. 8:93. (FC, ICC) PubMed Ambasudhan R, et al. 2011. Cell Stem Cell. 9(2):113. (IHC, ICC) Hu X., et al. 2006. Nature Neuroscicene. 9(12):1520. (WB) PubMed Zechner D., et al. 2003. Develop Biology. 258(2):406. (ICC, IHC) Lee MK, et al. 1990. Proc. Natl. Acad. Sci. USA 18:7195. (WB) Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations: Gai M, et al. 2016. EMBO Rep. 17: 1396 - 1409. PubMed Nonomura K, et al. 2016. Nature. 541:176-181. PubMed Ueki J, et al. 2017. Sci Rep. 7:42522. PubMed Fernandes HJR, et al. 2020. Cell Rep. 33:108263. PubMed Ko KW, et al. 2020. J Cell Biol. 219:00:00. PubMed Tilak M, et al. 2021. Molecular Cancer Research. 19(5):757-770. PubMed Alonso-Barroso E, et al. 2017. Stem Cell Research. 23:173-177. PubMed Wang YL, et al. 2021. Cell Reports. 36(8):109537. PubMed Tristan CA, et al. 2020. bioRxiv. . PubMed Abey A, et al. 2020. Brain Pathol. 31:144. PubMed Boyer NP, et al. 2018. Eneuro. 55:1847. PubMed Lee SW et al. 2018. Developmental cell. 46(1):73-84 . PubMed Chia PH et al. 2018. eLife. 7 pii: e32451. PubMed Erwig MS, et al. 2019. Elife. 8:. PubMed Tohgi N, et al. 2017. Cell Cycle. 16:95. PubMed Nicole O, et al. 2018. Mol Psychiatry. 23:2209. PubMed Kirihara T, et al. 2019. iScience. 14:301. PubMed Sanli I, et al. 2018. Cell Rep. 23:337. PubMed Croteau LP, et al. 2019. Sci Rep. 9:12009. PubMed Ioannou MS et al. 2019. Cell. 177(6):1522-1535 . PubMed Paonessa F et al. 2019. Cell reports. 26(3):582-593 . PubMed de la Cerda B et al. 2019. Stem cell research. 1726:26:00 . PubMed García‐Peña CM et al. 2018. Frontiers in neuroanatomy. 0.566666667 . PubMed Coleman JH, et al. 2017. J Comp Neurol. 525:3391. PubMed Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed Huang YA et al. 2017. Cell. 168(3):427-441 . PubMed Hegarty DM, et al. 2018. Pain Rep. 3:e664. PubMed Dai WJ, et al. 2019. Evid Based Complement Alternat Med. 2019:8413576. PubMed Wang XW, et al. 2020. Cell Rep. 31:107537. PubMed Woeste MA, et al. 2019. J Biol Chem. 294:3853. PubMed Tian R, et al. 2019. Neuron. 104:239. PubMed Urbaniak A, et al. 2022. Biomed Pharmacother. 153:113440. PubMed Dong C, et al. 2022. J Neurosci. 42:8373. PubMed Krasniewski LK, et al. 2022. Elife. 11:. PubMed Baek J, et al. 2022. Biomater Sci. 10:6768. PubMed Li TL, et al. 2022. Biomaterials. 290:121825. PubMed Cattelani C, et al. 2022. Int J Mol Sci. 23:. PubMed Chen WJ, et al. 2022. Adv Sci (Weinh). :e2205451. PubMed Wu J, et al. 2022. Methods Mol Biol. 2593:245. PubMed Whye D, et al. 2023. Curr Protoc. 3:e641. PubMed Dong Z, et al. 2023. J Biol Chem. 299:103020. PubMed Campbell B, et al. 2023. Sci Rep. 13:3000. PubMed Loan A, et al. 2023. iScience. 26:106093. PubMed Jimenez-Moreno N, et al. 2023. J Cell Biol. 222:. PubMed Panzi C, et al. 2023. Toxicon. 228:107110. PubMed Cossec JC, et al. 2023. Cell Rep. 42:112380. PubMed Eigenhuis KN, et al. 2023. Front Cell Neurosci. 17:1114420. PubMed Gilbert-Jaramillo J, et al. 2023. Biol Open. 12:. PubMed Sim KY, et al. 2023. Sci Rep. 13:6864. PubMed D'aes T, et al. 2023. Int J Mol Sci. 24:. PubMed Dawicki-McKenna JM, et al. 2023. Nat Commun. 14:2628. PubMed Paranjape N, et al. 2023. Sci Rep. 13:7689. PubMed Nguyen TTM, et al. 2023. iScience. 26:106674. PubMed Georgelou K, et al. 2023. Biomedicines. 11:. PubMed Kerkering J, et al. 2023. J Clin Invest. . PubMed Liang MZ, et al. 2023. Cell Biosci. 13:96. PubMed Lin CY, et al. 2023. J Food Drug Anal. 31:32. PubMed Martínez-Torres S, et al. 2023. iScience. 26:106814. PubMed Dos Santos BL, et al. 2023. Pharmaceutics. 15:. PubMed Stajkovic N, et al. 2023. J Cell Sci. . PubMed Drobny S, et al. 2023. Transl Neurodegener. 12:31. PubMed Zhang M, et al. 2023. Neurosci Bull. . PubMed Birsa N, et al. 2021. Sci Adv. 7: . PubMed Castelli LM, et al. 2021. Mol Neurodegener. 16:53. PubMed Nakayama T, et al. 2021. Cell Rep Med. 2:100421. PubMed Ye M, et al. 2021. Cell Death Dis. 12:1149. PubMed Seebauer L, et al. 2022. Int J Mol Sci. 23:. PubMed Zainul Z, et al. 2022. Sci Rep. 12:3344. PubMed Ahangari N, et al. 2021. J Neuropathol Exp Neurol. 80:944. PubMed Dang LT, et al. 2021. Dev Neurobiol. 81:696. PubMed Tsefou E, et al. 2021. Biochem J. 478:4099. PubMed Jacquier A, et al. 2022. Acta Neuropathol. 144:707. PubMed Wang Z, et al. 2022. Research (Wash D C). 2022:9832128. PubMed Schroeter MS, et al. 2022. MRS Bull. 47:530. PubMed Piermarini E, et al. 2022. Hum Mol Genet. 31:1844. PubMed Sun X, et al. 2022. Dev Cell. 57:112. PubMed Grigor'eva EV 2021. Stem Cell Research. 59:102651. PubMed Muralidharan H, et al. 2022. J Neurosci. 42:2149. PubMed Zhang A, et al. 2022. EMBO J. 41:e109187. PubMed Clements RT 2022. eneuro. 9(2). PubMed Sosnowski P, et al. 2022. Pharmaceuticals (Basel). 15: . PubMed Hallacli E, et al. 2022. Cell. 185:2035. PubMed Lin L, et al. 2022. J Comp Neurol. 530:2820. PubMed Park SY, et al. 2022. Int J Mol Sci. 23: . PubMed Hoye ML, et al. 2022. Elife. 11: . PubMed Wu X, et al. 2022. Cell Rep. 40:111085. PubMed Januel C, et al. 2022. Cell Mol Life Sci. 79:441. PubMed Frederico B, et al. 2022. Dev Cell. 57:1957. PubMed Xu J, et al. 2022. Small. 18:e2203431. PubMed Fleck JS, et al. 2022. Nature. :. PubMed Liu S, et al. 2023. CNS Neurosci Ther. 29:228. PubMed Radwitz J, et al. 2022. Cell Mol Life Sci. 79:575. PubMed Krasnova OA, et al. 2022. Int J Mol Sci. 23: . PubMed Vrathasha V, et al. 2022. iScience. 25:105308. PubMed Liu C, et al. 2022. Cell Mol Life Sci. 79:596. PubMed Koizumi M, et al. 2022. FASEB J. 36:e22662. PubMed Herdy JR 2022. Cell Stem Cell. 29(12):1637-1652.e6. PubMed Zhou Z, et al. 2023. Biol Pharm Bull. 46:102. PubMed Santiago-Mujika E, et al. 2023. J Alzheimers Dis Rep. 6:739. PubMed Xue W, et al. 2023. iScience. 26:105898. PubMed Jin S, et al. 2023. iScience. 26:105885. PubMed Day C, et al. 2023. Pharmaceuticals (Basel). 16: . PubMed Willumsen N, et al. 2023. Brain Commun. 5:fcac321. PubMed Choi EB, et al. 2023. J Biol Chem. 299:102996. PubMed Ma Y, et al. 2023. Eneuro. 10: . PubMed Wu W, et al. 2021. Nature. 593:440. PubMed Le Floch P, et al. 2022. Adv Mater. 34:e2106829. PubMed Alonso-Alonso S, et al. 2022. Reprod Fertil Dev. 34:576. PubMed Marrone L, et al. 2022. Hum Mol Genet. 31:2693. PubMed Hamrangsekachaee M, et al. 2022. ACS Appl Bio Mater. 5:2176. PubMed Lee J, et al. 2022. Nat Protoc. 17:1266. PubMed Xia F, et al. 2021. Acta Neuropathol Commun. 51:9. PubMed Shin BC, et al. 2021. Experimental Neurology. 338:113603. PubMed Wang D, et al. 2020. Journal of Biological Chemistry. 295(25):8374-8386. PubMed Khoa LTP, et al. 2020. Cell Stem Cell. 27(3):441-458.e10. PubMed Domènech EB, et al. 2020. Invest Ophthalmol Vis Sci. 61:14:00. PubMed Elhardt C, et al. 2020. Transl Vis Sci Technol. 9:06. PubMed Lee SE, et al. 2020. Cell Death Dis. 1.19375. PubMed Orozco-Díaz R, et al. 2019. PLoS One. 14:e0220393. PubMed Arber C, et al. 2019. Brain Commun. 1:fcz024. PubMed Valès S, et al. 2019. EBioMedicine. 49:172. PubMed Teissier A, et al. 2019. Mol Psychiatry. :. PubMed Macova I, et al. 2019. J Neurosci. 39:984. PubMed Inoue SI, et al. 2017. Hum Mol Genet. 26:4715. PubMed Shepherd DJ et al. 2017. Journal of neuropathology and experimental neurology. 76(8):683-696 . PubMed Kow Essuman et al. 2017. Neuron. 93(6):1334-1343 . PubMed Mangold CA et al. 2018. J Neurochem. 144(6):723-735 . PubMed Levin E et al. 2019. Cell reports. 26(4):1021-1032 . PubMed Murcia-Belmonte V, et al. 2019. Curr Biol. 29:1149. PubMed Daoutsali E et al. 2019. Stem Cell Res. 1723:19:00 . PubMed Ogawa Y et al. 2019. Neurosci Res. pii: S0168-0102(19)30120-8 . PubMed Tiethof AK, et al. 2018. Toxics. 6:52. PubMed Boso D, et al. 2019. Theranostics. 9:4860. PubMed Cha HL, et al. 2019. Mol Brain. 12:57. PubMed Wang G et al. 2019. eLife. 8 pii: e38730. PubMed Vinci M, et al. 2018. Nat Med. 24:1204. PubMed Laussu J, et al. 2017. Neural Dev. 12:10. PubMed Hu X, et al. 2019. Stem Cell Reports. 12:290. PubMed Valadas JS et al. 2018. Neuron. 98(6):1155-1169 . PubMed Ziller MJ, et al. 2018. Cell Stem Cell. 1.304861111. PubMed Park SY, et al. 2018. Mol Brain. 169:91. PubMed Babetto E, et al. 2020. Nat Neurosci. 23:1215. PubMed Eltahir MK, et al. 2022. PLoS One. 17:e0269683. PubMed Simoes S, et al. 2021. Cell Rep. 37:110182. PubMed Viais R, et al. 2021. Elife. 10:. PubMed Lafarga V, et al. 2021. EMBO J. 40:e103311. PubMed Kim S, et al. 2021. Nat Commun. 12:1807. PubMed Brown AL, et al. 2022. Nature. 603:131. PubMed Ruden JB, et al. 2021. Front Mol Neurosci. 14:777049. PubMed Tseng JH, et al. 2021. Cell Rep. 35:109037. PubMed Guo B, et al. 2021. Front Cell Dev Biol. 9:768970. PubMed Li F, et al. 2021. Nat Commun. 12:3845. PubMed Kishi N, et al. 2016. Nat Commun. 7:10520. PubMed Nawaz M, et al. 2016. PLoS One. 11: 0148634. PubMed Tao W, et al. 2020. EMBO Mol Med. 12:e12291. PubMed Bae B, et al. 2020. RNA. 26:1414. PubMed Halikere A, et al. 2020. Mol Psychiatry. 25:1406. PubMed Song JM, et al. 2021. The Journal of Neuroscience. 41(11):2344-2359. PubMed Benito-Kwiecinski S, et al. 2021. Cell. 184(8):2084-2102.e19. PubMed Bayerl J, et al. 2021. Cell Stem Cell. . PubMed Eriksen AZ, et al. 2021. Cell Stem Cell. 28(7):1205-1220.e7. PubMed Elsayed AK, et al. 2021. Stem Cell Research. 54:102433. PubMed Lpez-Mrquez A, et al. 2019. Stem Cell Research. 38:101469. PubMed Sood S, et al. 2020. Proc Natl Acad Sci U S A. 22331:117. PubMed Lim SH, et al. 2020. J Cell Sci. :133. PubMed Coste C, et al. 2017. PLoS One. 10.1371/journal.pone.0177962. PubMed Miranda AM, et al. 2018. Nat Commun. 9:291. PubMed Liu C, et al. 2018. Stem Cell Reports. 4:43. PubMed Lee SY et al. 2018. Stem cell research. 30:145-149 . PubMed Vitali I et al. 2018. Cell. 174(5):1264-1276 . PubMed Roselló-Busquets C, et al. 2019. Front Cell Neurosci. 13:40. PubMed Stepp MA, et al. 2018. Int J Mol Sci. 19:12. PubMed Miltner AM, et al. 2019. Int J Mol Sci. 20. PubMed Canali G, et al. 2018. Hum Mol Genet. 27:1941. PubMed Haverfield JT, et al. 2017. Reprod Fertil Dev. 29:609. PubMed Arellano‐Viera E et al. 2019. Stem cell research. 1726:10:00 . PubMed Ribic A et al. 2019. Cell reports. 26(2):381-393 . PubMed Varga E et al. 2017. Stem cell research. 25:30-33 . PubMed Nguyen HX et al. 2014. The Journal of comparative neurology. 522(12):2767-83 . PubMed Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed Giandomenico SL, et al. 2019. Nat Neurosci. 22:669. PubMed Stratton JA, et al. 2020. Front Aging Neurosci. 0.620833333. PubMed Yun T, et al. 2021. Cell Death Discov. 7:257. PubMed Herbst WA, et al. 2021. J Cell Biol. 220:. PubMed Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed Earley AM, et al. 2021. Sci Rep. 11:22257. PubMed Ramirez S, et al. 2021. STAR Protoc. 2:100987. PubMed Valenzuela M, et al. 2022. Stem Cell Res Ther. 13:261. PubMed Richardson RT, et al. 2021. Sci Rep. 11:11229. PubMed Guo X, et al. 2021. Cell. 184:4299. PubMed Vilallongue N, et al. 2022. Nat Commun. 13:6040. PubMed Lennox AL, et al. 2020. Neuron. 404:106. PubMed Pecori F, et al. 2021. Cell Reports. 36(2):109361. PubMed Aarts CEM, et al. 2021. Stem Cell Research. 54:102444. PubMed Zhang K, et al. 2021. Neuron. 109(12):1949-1962.e6. PubMed Aprigliano R, et al. 2021. Cell Reports Medicine. 2(4):100240. PubMed Pantier R, et al. 2021. Molecular Cell. 81(4):845-858.e8. PubMed Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed Toma JS, et al. 2020. Eneuro. 7:00. PubMed Solis-Castro OO, et al. 2020. Stem Cells Transl Med. 1.390277778. PubMed Ucuncu E, et al. 2020. Nat Commun. 4.685416667. PubMed LI Y, et al. 2017. Proc Natl Acad Sci U S A. 114(2):E209-E218. PubMed Jiang G, et al. 2016. Stem Cells Trans Med. 5(12):1595-1606. PubMed Martin C, et al. 2016. Genes Dev. 30: 2158 - 2172. PubMed Kida H, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw134. PubMed Savino E, et al. 2020. Cell Death Dis. 1.052777778. PubMed Saito K, et al. 2019. Cell Rep. 29:1555. PubMed Lilian SJ, et al. 2019. J Assoc Res Otolaryngol. 20:133. PubMed Milbreta U, et al. 2019. Mol Ther. 27:411. PubMed Arai Y, et al. 2019. Cell Rep. 29:645. PubMed Bucan V, et al. 2019. Int J Mol Med. 43:593. PubMed Petkovich DA et al. 2017. Cell metabolism. 25(4):954-960 . PubMed Auboyer L et al. 2019. Stem Cell Res. 1727:38:00 . PubMed Tomassoni–Ardori F, et al. 2019. Elife. 8:e46677. PubMed Van Der Raadt J, et al. 2019. Nucleic Acids Res. 47:5587. PubMed Raspa A, et al. 2019. CNS Neurosci Ther. 25:86. PubMed González C, et al. 2018. Mol Psychiatry. 23:2363. PubMed Liu H, et al. 2019. Front Cell Neurosci. 13:60. PubMed Mura M et al. 2018. Stem cell research. 29:170-173 . PubMed Hermanto Y et al. 2018. Journal of neuroscience research. 96(5):863-874 . PubMed Playne R, et al. 2018. J Stem Cells Regen Med. 7:e36998. PubMed Allende ML, et al. 2018. J Lipid Res. 59:550. PubMed Masumoto K, et al. 2022. Sci Rep. 12:10351. PubMed McClellan S, et al. 2021. Invest Ophthalmol Vis Sci. 62:14. PubMed Hagihara H, et al. 2021. Cell Rep. 37:109820. PubMed Boussaad I, et al. 2021. Sci Rep. 11:1439. PubMed Savino E, et al. 2021. Cells. 10:. PubMed Liu X, et al. 2021. Cell Prolif. 54:e13124. PubMed Doron-Mandel E, et al. 2021. EMBO J. 40:e107158. PubMed Kim K, et al. 2015. PLoS One. 10: 0142693. PubMed Mazzulli J, et al. 2016. Proc Natl Acad Sci U S A. 113: 1931 - 1936. PubMed Soares V, et al. 2016. Neuro Oncology. 10.1093/neuonc/now099. PubMed Mikami Y, et al. 2016. EBioMedicine. 11: 253-261. PubMed Pal-Ghosh S, et al. 2020. Invest Ophthalmol Vis Sci. 61:01:00. PubMed Janz A, et al. 2021. Stem Cell Research. 53:102256. PubMed Janssens S, et al. 2018. mSystems. 3. PubMed Thomas RA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed Tripathy R, et al. 2018. Neuron. 100:1354. PubMed Lenz KM, et al. 2018. J Neurosci. 38:8044. PubMed Nam H et al. 2019. Elife. 8 pii: e46683. PubMed Boucherie C, et al. 2018. Mol Psychiatry. 23:723. PubMed Leibinger M et al. 2019. Commun Biol. 0.304166667 . PubMed Mura M et al. 2019. Stem Cell Res. 1727:37:00 . PubMed Hansen M et al. 2017. Stem cell research. 25:34-37 . PubMed Yang SC, et al. 2019. FASEB J. 33:10577. PubMed Qiang L, et al. 2019. Hum Mol Genet. 28:1136. PubMed Iwasa N, et al. 2021. Front Cell Neurosci. 15:605030. PubMed Boshans LL, et al. 2021. Sci Rep. 11:3552. PubMed Weiss FD, et al. 2021. Nat Commun. 12:2919. PubMed Mallach A, et al. 2021. Cells. 10:. PubMed Hernandez-Clavijo A, et al. 2022. Cell Physiol Biochem. 56:254. PubMed Wang W, et al. 2021. EMBO J. 40:e106771. PubMed Lin YC, et al. 2021. Nat Neurosci. 24:1077. PubMed Lim JY, et al. 2021. Stem Cell Res Ther. 12:402. PubMed Mifsud KR, et al. 2021. Nat Commun. 12:4737. PubMed Li Y, et al. 2022. Front Neurosci. 16:945277. PubMed Mura M, et al. 2019. Stem Cell Research. 42:101658. PubMed Alkobtawi M, et al. 2021. Cell Reports. 35(12):109289. PubMed Li W, et al. 2021. Stem Cell Research. 53:102259. PubMed Haas M, et al. 2016. Cell Rep. 15:2251-2265. PubMed Itoh Y, et al. 2016. Proc Natl Acad Sci U S A. 113: 2955 - 2964. PubMed Nagao M, et al. 2016. Nat Commun. 7:11102. PubMed Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed Ulbrich L, et al. 2016. Biochem J. 473: 423 - 434. PubMed Barry D, et al. 2012. J Neurosci. 32:6209-6219. PubMed Catanese A, et al. 2019. Autophagy. 15:1719. PubMed Pettingill P, et al. 2019. Brain. 142:3852. PubMed Wang SE, et al. 2019. Exp Neurobiol. 28:537. PubMed Song Z, et al. 2019. Front Cell Dev Biol. 0.352083333. PubMed Wang L et al. 2016. The Journal of comparative neurology. 524(11):2322-34 . PubMed Hansen M et al. 2017. Stem cell research. 25:42-45 . PubMed Herdy J et al. 2019. Elife. 8 pii: e41356. PubMed Vicario N et al. 2019. Molecular neurobiology. 56(11):7338-7354 . PubMed Child KM et al. 2018. The Journal of Neuroscience. 38(31):6806-6824 . PubMed Fujitani M, et al. 2017. Mol Psychiatry. 22:364. PubMed Hockman D, et al. 2018. Dev Biol. 444:s308. PubMed Barbiero I, et al. 2017. Hum Mol Genet. 26:3520. PubMed Coleman JH, et al. 2019. J Neurosci. 39:814. PubMed Luo C et al. 2019. eLife. 8 pii: e40197. PubMed Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed Knudsen JG et al. 2018. Cell metabolism. 29(2):430-442 . PubMed Millan‐Zambrano G et al. 2018. Molecular cell. 72(4):625-635 . PubMed Sevilla A et al. 2018. Stem cell research. 29:99-102 . PubMed Muthusamy N, et al. 2018. Sci Rep. 8:1766. PubMed Iyer AA, et al. 2022. Elife. 11:. PubMed Cheng Y, et al. 2022. Nat Commun. 13:4418. PubMed Ramirez S, et al. 2021. Cells. 10:. PubMed Wareham LK, et al. 2021. iScience. 24:103141. PubMed Abe K, et al. 2021. Biophys J. 120:3566. PubMed Caiazzo M, et al. 2016. Nat Mater. 0.1038/nmat4536. PubMed Fan C, et al. 2016. Sci Rep. 6:19579. PubMed Vanderperre B, et al. 2016. PLoS Genet. 12: 1006056. PubMed Wang T, et al. 2016. Nat Commun. 7: 12976. PubMed Pei S, et al. 2016. Sci Rep. 6:33822. PubMed M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed Ahn LY, et al. 2021. J Neurosci Res. 99:110. PubMed Black JB, et al. 2020. Cell Rep. 33:108460. PubMed Birkhoff JC, et al. 2020. Hum Mol Genet. 29:2535. PubMed Pereiro X, et al. 2020. Cells. 9:00. PubMed Berenguer-Escuder C, et al. 2020. Human Molecular Genetics. 29(8):1353-1364. PubMed Tapias A, et al. 2021. eLife. 10:00. PubMed Dong L, et al. 2021. Stem Cell Research. 53:102260. PubMed Zhang T, et al. 2021. STAR Protocols. 2(1):100346. PubMed Arribas-Carreira L, et al. 2019. Stem Cell Research. 39:101503. PubMed Schoger E, et al. 2021. Stem Cell Research. 56:102518. PubMed Klima S, et al. 2020. ALTEX. . PubMed Kuwahara H, et al. 2018. Sci Rep. 8:4377. PubMed Anne Jacob et al. 2018. Journal of neurochemistry. 146(3):251-268 . PubMed Lehrman EK et al. 2018. Neuron. 100(1):120-134 . PubMed Valdez C, et al. 2017. Hum Mol Genet. 26:4861. PubMed Moakley D, et al. 2019. Sci Rep. 9:10835. PubMed Malkemper EP, et al. 2018. Biol Open. 7:bio034462. PubMed Stratton JA et al. 2018. Cell reports. 24(10):2561-2572 . PubMed Neurohr GE, et al. 2019. Cell. 176:1083. PubMed Hermanto Y et al. 2019. Journal of neuroscience research. 97(7):828-845 . PubMed An D, et al. 2019. Elife. 8:e44423. PubMed Voronova A et al. 2017. Neuron. 94(3):500-516 . PubMed Hilla AM et al. 2017. The Journal of Neuroscience. 37(25):6113-6124 . PubMed Bustos F, et al. 2018. Cell Rep. 2.06875. PubMed Mayanagi T, et al. 2020. Front Cell Neurosci. 0.933333333. PubMed Arsić A, et al. 2020. Sci Rep. 10:6441. PubMed Edwards G, et al. 2020. Cell Death Dis. 11:254. PubMed Nishimura K, et al. 2017. PLoS One. 12:e0170568. PubMed Roselló-Busquets C, et al. 2020. Front Mol Neurosci. 13:56. PubMed Wang X, et al. 2019. Front Neurosci. 1.324305556. PubMed Guerriero I, et al. 2021. PLoS One. 16:e0253828. PubMed Diao X, et al. 2021. Cells. 10:. PubMed Lamotte JD, et al. 2021. Front Pharmacol. 11:617867. PubMed Paik S, et al. 2021. Biomedicines. 9:. PubMed Nehme R, et al. 2022. Nat Commun. 13:3690. PubMed Xia L, et al. 2022. Front Pharmacol. 13:881195. PubMed Zhang L, et al. 2022. Front Aging Neurosci. 14:926485. PubMed Lu P, et al. 2022. Invest Ophthalmol Vis Sci. 63:18. PubMed Heuermann ML, et al. 2022. Front Cell Neurosci. 16:841864. PubMed McSweeney D, et al. 2022. iScience. 25:105187. PubMed Lasman L, et al. 2020. Genes Dev. 34:1373. PubMed Wong HS, et al. 2021. Cell. . PubMed Kim JW, et al. 2020. Cell Stem Cell. 27(4):633-645.e7. PubMed Evsen L, et al. 2020. Development. 147:00:00. PubMed Huang YA, et al. 2020. J Cell Sci. 133:00:00. PubMed Levin G, et al. 2020. Front Bioeng Biotechnol. 0.663888889. PubMed Seo HH, et al. 2020. Emerg Microbes Infect. 1.724305556. PubMed Laura Kerosuo, Marianne E. Bronner 2016. Cell Rep. 17:2648-2659. PubMed George L, et al. 2016. Dev Biol. 413:70-85. PubMed Ferletta M, et al. 2011. Int J Cancer. 129:45-60. PubMed Banal C, et al. 2020. Stem Cell Research. 72.78888889. PubMed Zhao J, et al. 2020. Aging (Albany NY). 12:5590. PubMed Themeli M, et al. 2020. Stem Cell Reports. 14:300. PubMed Ding D, et al. 2020. J Otol. 15:36. PubMed Ilouz R et al. 2017. eLife. 6 pii: e17681. PubMed Kwart D et al. 2019. Neuron. 104(2):256-270 . PubMed Di Bella DJ, et al. 2019. Cell Rep. 28:2264. PubMed Velychko S et al. 2019. Cell reports. 27(1):30-39 . PubMed Kim J, et al. 2018. Development. 145. PubMed Yang T et al. 2018. Cell reports. 24(10):2694-2708 . PubMed Cheng LS, et al. 2017. Pediatr Res. 81:838. PubMed Augé E, et al. 2018. Sci Rep. 8:13525. PubMed Shin BC et al. 2018. The Journal of Neuroscience. 38(44):9579-9599 . PubMed Cárdenas A et al. 2018. Cell. 174(3):590-606 . PubMed Goffena J, et al. 2018. Nat Commun. 9:889. PubMed Ogawa Y, et al. 2017. PLoS One. 12(6):e0178978. PubMed Ha GH, et al. 2022. Aging (Albany NY). 14:. PubMed Meyer Zu Reckendorf S, et al. 2022. J Neurosci. 42:2474. PubMed van Niekerk EA, et al. 2022. Cell Rep Methods. 2:100255. PubMed Nouri P, et al. 2022. Cells. 11:. PubMed Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed Fagerlund I, et al. 2021. Cells. 11:. PubMed Petrovic A, et al. 2022. Int J Mol Sci. 23:. PubMed Colombo S, et al. 2022. Development. 149:. PubMed Sidoli M, et al. 2021. J Neurosci. 41:4536. PubMed Simone R, et al. 2021. Nature. 594:117. PubMed Li A, et al. 2021. STAR Protoc. 2:100580. PubMed Osuka S, et al. 2021. J Clin Invest. 131: . PubMed Wirt S, et al. 2010. J Cell Biol. 191:809-825. PubMed Wang Q, et al. 2016. Sci Rep. 6:19003. PubMed Petracca Y, et al. 2016. Development. 143: 880 - 891. PubMed Lalli M, et al. 2016. Hum Mol Genet. 25: 1294-1306. PubMed Thakurela S, et al. 2016. Sci Rep. 6: 25828. PubMed Bedogni F, et al. 2016. Cereb Cortex. 26: 2517 - 2529. PubMed Landegger L, et al. 2017. Nat Biotechnol. 35:280-284. PubMed Pournasr B, et al. 2020. Stem Cell Res. 48:101953. PubMed Trapecar M, et al. 2021. Sci Adv. 7:00. PubMed Smith KE, et al. 2020. Journal of Neuroscience Research. 99(2):679-698. PubMed Isaja L, et al. 2021. Stem Cell Research. 53:102325. PubMed Elsayed AK, et al. 2021. Stem Cell Research. 56:102500. PubMed Bargagna-Mohan P, et al. 2020. J Neurosci Res. . PubMed Lee N, et al. 2021. Biochem Biophys Rep. 100973:26. PubMed Chau KF, et al. 2018. Elife. 19:E663. PubMed Sun S et al. 2018. Cell. 174(5):1247-1263 . PubMed Yi‐Lan Weng et al. 2018. Neuron. 97(2):313-325 . PubMed Bachmann SO, et al. 2019. Transl Psychiatry. 9:29. PubMed Sabo JK, et al. 2017. Ann Neurol. 81:560. PubMed Gao L, et al. 2019. Front Cell Neurosci. 13:316. PubMed Shao Q et al. 2019. PLoS One. 14(6):e0218811 . PubMed Mohlin S, et al. 2019. EMBO Mol Med. 11:e10058. PubMed Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed Duan RS, et al. 2018. Cell Death Differ. 25:1598. PubMed Pollen AA, et al. 2019. Cell. 176:743. PubMed Corman A, et al. 2019. Cell Chem Biol. 26:235. PubMed Molotkov A et al. 2017. Developmental cell. 41(5):511-526 . PubMed Yang C, et al. 2020. Neuron. 105:276. PubMed Marchetta P, et al. 2020. Front Aging Neurosci. 12:83. PubMed Zheng Z, et al. 2021. Cell Biol Toxicol. Online ahead of prin. PubMed Lim SH, et al. 2020. J Cell Sci. . PubMed Salti A, et al. 2021. Cells. 10:. PubMed Araki R, et al. 2021. Heliyon. 7:e08071. PubMed Ye E, et al. 2022. Int J Oncol. 60:. PubMed Taïb S, et al. 2022. Elife. 11:. PubMed Bérenger-Currias NM, et al. 2022. J Tissue Eng. 13:20417314221103042. PubMed Urciuolo A, et al. 2020. Nat Biomed Eng. 4:901. PubMed Sadick JS, et al. 2020. Ann Biomed Eng. 48:2218. PubMed Lecomte A, et al. 2020. Adv Biosyst. e2000114:4. PubMed Wang L, et al. 2020. Nat Commun. 3.2625. PubMed Sheehan CJ, et al. 2020. Development. 147:00:00. PubMed Zabolocki M, et al. 2020. Nat Commun. 4.3125. PubMed Liu R, et al. 2021. Oncol Lett. 21:06. PubMed Zhang X, et al. 2020. Sci Adv. 6:00. PubMed Sadick J, et al. 2016. Sci Rep. 6: 33999. PubMed Guo S, Du Y, Liu X 2016. Nat Commun. 7:12230. PubMed Kushwaha R, et al. 2016. Stem Cell Reports. 6:772-783. PubMed Paquet D, et al. 2016. Nature. 533: 125-129. PubMed Binder Z, et al. 2016. PLoS One. 11: 0150271. PubMed He H, et al. 2016. J Neurosci. 36: 3079 - 3091. PubMed Khong ZJ, et al. 2020. Cell Death Dis. 11:182. PubMed Pinheiro H, et al. 2018. Front Pharmacol. 0.527083333. PubMed Ichihara–Tanaka K, et al. 2017. J Histochem Cytochem. 65:513. PubMed Harrington AJ et al. 2016. eLife. 5 pii: e20059. PubMed Michael Lerche et al. 2017. Structure (London, England : 1993). 25(8):1175-1186 . PubMed Larhammar M et al. 2017. eLife. 6 pii: e20725. PubMed Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed Freeman S et al. 2019. EMBO Rep. 20(9):e47097 . PubMed Kaur T, et al. 2019. Front Neurosci. 13:620. PubMed Nash B et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed Sarkar C, et al. 2019. Autophagy. N/A. PubMed Tramarin M, et al. 2018. Hum Mol Genet. 27:2052. PubMed Xue J, et al. 2017. ACS Appl Mater Interfaces. 9:12299. PubMed Toda T, et al. 2017. Cell Stem Cell. 21:618. PubMed Amaral JD, et al. 2019. Front Chem. 7:15. PubMed Wang XW, et al. 2018. Cell Rep. 24:2540. PubMed Tavano S et al. 2018. Neuron. 97(6):1299-1314 . PubMed Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed Fujiwara N, et al. 2022. Pediatr Surg Int. 39:18. PubMed Zhu Z, et al. 2022. Aging Cell. 21:e13587. PubMed Schaeffer J, et al. 2022. Front Cell Dev Biol. 10:917589. PubMed Li J, et al. 2021. Neural Plast. 2021:4894881. PubMed Wilmerding A, et al. 2021. Int J Mol Sci. 22:. PubMed Hu D, et al. 2021. Nat Commun. 12:5305. PubMed Russo-Savage L, et al. 2020. Neurobiol Aging. 95:69. PubMed Pinto M, et al. 2016. J Cell Biol. 212: 789 - 801. PubMed Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed Liu X, et al. 2016. Nat Commun. 7:11508. PubMed Grandi FC, et al. 2020. Front Mol Neurosci. 0.599305556. PubMed Ewan EE, et al. 2021. Sci Rep. 0.718055556. PubMed Brievac D, et al. 2020. Journal of Neurochemistry. 157(3):666-683. PubMed Hu Z, et al. 2020. Cell Rep. 107657:31. PubMed Lehtonen Ŝ et al. 2018. Stem cell research. 30:96-99 . PubMed Qiang L et al. 2018. Current biology : CB. 28(13):2181-2189 . PubMed Hor JH, et al. 2018. Cell Death Dis. 9:1100. PubMed Gupta S et al. 2017. Journal of neurochemistry. 145(3):188-203 . PubMed Howlett EH, et al. 2017. Hum Mol Genet. 26:4340. PubMed Zunke F et al. 2017. Neuron. 97(1):92-107 . PubMed Fernandes KA, et al. 2018. Exp Eye Res. 171:54. PubMed Linkous A et al. 2019. Cell reports. 26(12):3203-3211 . PubMed Pronin A, et al. 2019. Front Mol Neurosci. 12:36. PubMed Meijer M et al. 2019. Cell Rep. 27(7):2199-2211 . PubMed Lin CI et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed Auboyer L et al. 2019. Stem Cell Res. 1723:41:00 . PubMed Kurtenbach S et al. 2017. PloS one. 12(11):e0187576 . PubMed Yu M et al. 2017. Cell research. 27(12):1441-1465 . PubMed Huh CJ et al. 2016. eLife. 5 pii: e18648. PubMed Li J, et al. 2018. Neural Plast. 2018:6890613. PubMed Chen YT, et al. 2019. Stem Cell Res Ther. 0.6875. PubMed Syal C, et al. 2020. Theranostics. 10:6337. PubMed de Matos AM, et al. 2020. J Med Chem. 63:11663. PubMed Calamini B, et al. 2021. Dis Model Mech. 14:. PubMed Gandhi S, et al. 2021. Development. 148:. PubMed Stern S, et al. 2021. Neuron. 109:3436. PubMed Nath M, et al. 2022. Eneuro. 9:. PubMed Xu PF, et al. 2021. Nature Communications. 12(1):3277. PubMed Anderson EM, et al. 2021. Addiction Biology. :e13060. PubMed Lin NH, et al. 2021. The FASEB Journal. 35(5):e21614. PubMed Leibinger M, et al. 2021. Nature Communications. 12(1):391. PubMed Huang S, et al. 2020. Cell Rep. 33:108394. PubMed Rubio A, et al. 2016. Sci Rep. 6:37540. PubMed Intoh A, et al. 2016. Hum Mol Genet. 10.1093/hmg/ddw053. PubMed Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed Jouhilahti E, et al. 2008. J Histochem Cytochem. 56:1113-1119. PubMed Gilliam EA, et al. 2020. American Journal of Physiology-Gastrointestinal and Liver Physiology. 319(2):G261-G279.. PubMed Dionisi C, et al. 2020. Sci Rep. 10:7752. PubMed Lindsay CD, et al. 2019. Acta Biomater. 95:225. PubMed Makdissy N, et al. 2018. Stem Cell Res Ther. 0.466666667. PubMed Mettang M, et al. 2018. FASEB J. 32:1916. PubMed Chen X et al. 2017. Developmental cell. 43(5):563-576 . PubMed Hegarty DM, et al. 2017. J Comp Neurol. 525:2019. PubMed Tsuboi M, et al. 2018. Dev Cell. 47:758. PubMed Sharma N et al. 2019. Neuron. 102(2):390-406 . PubMed Mo J, et al. 2017. Invest Ophthalmol Vis Sci. 58:137. PubMed Rhee HJ et al. 2019. Cell Rep. 27(7):2212-2228 . PubMed Makar T, et al. 2018. Stem Cell Res Ther. 9:127. PubMed Debadrita Bhattacharya et al. 2018. eLife. 7 pii: e40556. PubMed Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed Kim YJ, et al. 2018. Neuron. 100:1180. PubMed Contreras E, et al. 2022. Cell Tissue Res. :. PubMed Sluysmans S, et al. 2021. Mol Biol Cell. 32:ar34. PubMed Ma C, et al. 2022. Int J Mol Med. 50:. PubMed Khan M, et al. 2021. Cell. 184:5932. PubMed Xue Y, et al. 2016. Nat Neurosci. 19: 807-15. PubMed Muscat A, et al. 2016. Clin Cancer Res. 22: 3560 - 3570. PubMed Sandor C, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw412. PubMed Ingersoll MA, et al. 2020. Sci Adv. 6:00. PubMed Jiang B, et al. 2020. Sci Adv. 6:00. PubMed Barbuti PA, et al. 2020. Cells. 9:00. PubMed Vila-Cejudo M, et al. 2018. Journal of Assisted Reproduction and Genetics. 36(1):99-111. PubMed Koinuma S, et al. 2020. Journal of Neurochemistry. 157(4):1196-1206. PubMed Dementyeva EV, et al. 2021. Stem Cell Research. 53:102344. PubMed Han JS, et al. 2020. Proc Natl Acad Sci U S A. 23073:117. PubMed Gupta S, et al. 2021. STAR Protoc. 100319:2. PubMed Hertzano R, et al. 2020. Laryngoscope. . PubMed Flaherty E,et al. 2017. NPJ Schizophr.. 10.1038/s41537-017-0033-5. PubMed Ryan T, et al. 2018. Nat Commun. 9:817. PubMed Moon KH et al. 2018. Developmental cell. 44(1):13-28 . PubMed Xu Z, et al. 2019. Front Neurosci. 12:970. PubMed Joanna Ruth Ap