Biolegend, 815301, Purified anti-HDAC3 Antibody (Previously Covance catalog# MMS-5073), 100microl

HDAC-3, also known as RPD3-2 and SMAP45, is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression, and other developmental related functions. HDAC-3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also thought to participate in transcriptional regulation through binding to YY1, a zinc-finger transcription factor.
100microl
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This monoclonal antibody was raised against a peptide sequence derived from the C-terminus of the human HDAC3 protein.
Formulation: Phosphate-buffered solution.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 1 mg/ml
Storage & Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody is effective in formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).
RRID: AB_2564791 (BioLegend Cat. No. 815301)
Biology Area: Cell Biology, Neuroscience
Gene ID: 8841
UniProt: View information about HDAC3 on UniProt.org
Clone: 3G6
Regulatory Status: RUO
Other Names: Histone deacetylase 3, SMAP45, RPD3-2
Previously: Covance Catalog# MMS-5073
Isotype: Mouse IgG2a, κ