Biolegend, 831603, APC anti-Annexin A1, 25tests

Annexin1 (also known as Lipocortin-1) is a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. Phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes. Lipocortin-1 has phospholipase A2 inhibitory activity, thus therefore it is an anti-inflammatory protein.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This monoclonal antibody was raised against AG1523 human fibroblast cells.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
Additional Product Notes: FC Positive Control: K562 Cell Line
Product Citations: Perez GI, et al. 2023. Vaccines (Basel). 11:. PubMed Lawrence M, et al. 2022. Sci Adv. 8:eabj8618. PubMed
RRID: AB_2686933 (BioLegend Cat. No. 831603) AB_2686934 (BioLegend Cat. No. 831604)
Biology Area: Cell Biology, Neuroinflammation, Neuroscience
Molecular Family: Phospho-Proteins
Gene ID: 301
UniProt: View information about Annexin A1 on UniProt.org
Clone: 74/3
Regulatory Status: RUO
Other Names: Lipocortin-1, p35, annexin-1, calpactin-2, calpactin II, lipocortin I, chromobindin-9, annexin I (lipocortin I), phospholipase A2 inhibitory protein
Isotype: Mouse IgG1, κ