Biolegend, 853002, Purified anti-Transthyretin, 31-50 Antibody, 100μg

Transthyretin (TTR) is a carrier protein capable of transporting thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. TTR can form aberrant insoluble amyloid fibrils that primarily deposit in a patient’s heart and/or peripheral nerves. The wild-type protein is associated with senile systemic amyloidosis (SSA) and is typically diagnosed in men over 70 years-old. Single or double mutations in TTR are primarily associated with familial amyloidotic polyneuropathy (FAP) or familial amyloid cardiopathy (FAC), affecting younger patients (in their 30s).Clinical symptoms of TTR amyloidosis have historically been attributed to fibrils, but recent experimental evidence indicates that soluble TTR aggregates are also pathogenic.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant Human Transthyretin
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Qulaity testedDirect ELISA - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For Direct ELISA applications, a concentration range of 0.002 - 0.2 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2728603 (BioLegend Cat. No. 853001) AB_2728604 (BioLegend Cat. No. 853002)
Structure: TTR is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
Distribution: Tissue sources: Liver, choroid plexus epithelium, and retina pigment epithelium. Distribution: Primarily extracellular in blood and cerebrospinal fluid.
Function: The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
Interaction: Perlecan, receptor for advanced glycation end product (RAGE)
Ligand/Receptor: Thyroxine, retinol-binding protein bound to retinol
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Carrier Proteins
Antigen References: Plante-Bordeneuve V, et al. 2011. Lancet Neurol. 10:1086. PubMed Pinney JH, et al. 2013. J Am Heart Assoc. 2:e000098. PubMed Hawkins PN, et al. 2015. Ann Med. 47(8):625. PubMed
Gene ID: 7276
UniProt: View information about Transthyretin 31-50 on UniProt.org
Clone: CPTC-TTR-1
Regulatory Status: RUO
Other Names: PALB, ATTR, Prealbumin, TBPA
Isotype: Mouse IgG2a, κ