Biolegend, 853802, Purified anti-Chil3 Antibody, 100μg

Chitinases are hydrolytic enzymes that break down glycosidic bonds in chitin. Chitinase-like protein 3 (Chil3) hydrolyzes terminal non-reducing N-acetyl-D-hexosamine residues into N-acetyl-beta-D-hexosaminides. This protein is particular enriched in the spleen.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant mouse Chil3
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2750120 (BioLegend Cat. No. 853801) AB_2750121 (BioLegend Cat. No. 853802)
Structure: Chil3 is a 398 amino acid protein with a molecular weight mass of ~45 kD.
Distribution: Tissue distribution: Spleen, macrophages, and bone marrow-derived neutrophils. Cellular distribution: Nucleus, endoplasmic reticulum, and secreted.
Function: Chil3 plays a role in hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Interaction: Chil3 binds to chitin, lectin, and heparin.
Cell Type: Macrophages, Neutrophils
Biology Area: Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family: Enzymes and Regulators
Antigen References: Mesci P, et al. 2015. Brain. 138:53-68 Wu F, et al. 2016. Parasitol Res. 115:3737 Al-Rubaie A, et al. 2018. Respir Res. 19:114
Gene ID: 12655
UniProt: View information about Chil3 on UniProt.org
Clone: A17046B
Regulatory Status: RUO
Other Names: Chitinase-like protein 3, Chil3, Beta-N-acetylhexosaminidase Ym1, Ym1, ECF-L, Eosinophil chemotactic cytokine
Isotype: Rat IgG2a, κ