Biolegend, 859901, Purified anti-MOG Antibody, 25μg

Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. It is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication, and mediate homophilic cell-cell adhesion. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. MOG may also act as a receptor for rubella virus during microbial infection.
25μg
Verified Reactivity: Human
Antibody Type: Polyclonal
Host Species: Rabbit
Immunogen: Recombinant MOG expressed in E.coli.
Formulation: 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Schindler CR, et al. 2024. Front Immunol. 1347767:15. PubMed
RRID: AB_2810735 (BioLegend Cat. No. 859901)
Structure: MOG is a 247 amino acid protein with an apparent molecular mass of ~28 kD.
Distribution: Tissue Distribution: Brain and spinal cord Cellular Distribution: Plasma membrane
Function: MOG is involved in completion and maintenance of the myelin sheath and cell-cell communication.
Interaction: Myelin, Rubella virus
Cell Type: Neurons, Oligodendrocytes
Biology Area: Cell Adhesion, Immunology, Neurodegeneration, Neuroscience, Stem Cells
Molecular Family: Adhesion Molecules, Innate Immune Signaling
Antigen References: Reindl M, et al. 2017. Curr Opin Neurol. 30(3):295. Hennes EM, et al. 2018. Neuropediatrics. 49(1):3.
Gene ID: 43401744124558
UniProt: View information about MOG on UniProt.org
Clone: Poly28599
Regulatory Status: RUO
Other Names: MOG, Myelin Oligodendrocyte Glycoprotein
Isotype: Rabbit Polyclonal IgG