Biolegend, 866202, Purified anti-RCAN1 Antibody, 100μg

RCAN1 is a protein that inhibits the calcineurin/NFAT signaling pathway via it’s interaction with calcineruin A. RCAN1 has three different transcript variants, among which RCAN1.4 has been shown to regulate gene expression, cell migration and tubular morphogenesis in endothelial cells. Dysfunction of RCAN1 has been reported to impact the development of central nervous system, and is clinically linked to Down syndrome. It has also been reported that chronic overexpression of RCAN1 leads to formation of neurofibrillary tangles (NFT), and thus may play a role in neurodegenerative diseases such as AD.
100μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human RCAN1
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2814606 (BioLegend Cat. No. 866201) AB_2814607 (BioLegend Cat. No. 866202)
Structure: RCAN1 is a 252 amino acid protein with predicted molecular mass of ~ 28 kD, and observed molecular masses of ~ 35 kD (RCAN1L) and ~24 kD (RCAN1S) by WB.
Distribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus and Cytosol
Function: RCAN1 inhibits the calcineurin/NFAT signaling pathway
Interaction: RAF1, PPP3CA, PPP3R1, Calcineurin A
Cell Type: Microglia
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction, Synaptic Biology
Antigen References: Porta S, et al. 2007. Hum Mol Genet. 16(9):1039 Torac E, et al. 2014. J Med Life. 7(4):481 Wu Y, et al. 2014, Mol Neurobiol. 50(3):1085 Harris CD, et al. 2005. Cell Mol Life Sci. 62(21):2477
Gene ID: 182754720266766
UniProt: View information about RCAN1 on UniProt.org
Clone: A18067A
Regulatory Status: RUO
Other Names: Regulator of Calcineurin 1, DSCR1
Isotype: Mouse IgG2b, κ