Biolegend, 866601, Purified anti-PRDX4 Antibody, 25μg

Peroxiredoxins (PRDXs) are a ubiquitously expressed small molecule family of proteins (22-27 kD) regulating peroxide reduction of H 2 O 2 and cellular homeostasis. The protective role of PRDXs is well established in cardiovascular diseases, neurological disorders and cancers. PRDX4 is an ER enzyme that acts as a H 2 O 2 sensor. In the brain, PRDX4 regulates neurogenesis via controlling the surface expression of glycerophosphodiester phosphodiesterase 2. In human glioblastomas, the expression of PRDX4 is markedly increased. In vitro, suppression of PRDX4 in glioblastoma cells induces apoptosis and reduces tumor growth.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant full length protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810789 (BioLegend Cat. No. 866601) AB_2810790 (BioLegend Cat. No. 866602)
Structure: Human PRDX4 is a 271 amino acid protein with a molecular mass of 31 kD.
Distribution: Tissue distribution: Ubiquitously expressed Cellular distribution: Endoplasmic reticulum
Function: PRDX4 is involved in cell protection against oxidative stress by detoxifying peroxides and acting as sensor of hydrogen peroxide-mediated signaling events.
Interaction: Interacts with PRDX1
Cell Targets: Hydrogen peroxide
Cell Type: Neural Stem Cells, Neurons
Biology Area: Neurodegeneration, Neuroscience
Molecular Family: Enzymes and Regulators
Antigen References: Yan Y, et al. 2015. Nat. Commun. 6:7006. Kim T.H. et al. 2012. PLoS One. 7(8):e42818.
Gene ID: 10549
UniProt: View information about PRDX4 on UniProt.org
Clone: CPTC-PRDX4-1
Regulatory Status: RUO
Other Names: Peroxiredoxin-4, Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, PRX-4, Thioredoxin Peroxidase (Antioxidant Enzyme)
Isotype: Mouse IgG2a, κ