Biolegend, 867401, Purified anti-SLC6A1 Antibody, 25μg

SLC6A1 is the gene that encodes GABA transporter 1 (GAT1) and functions as the major presynaptic protein in neurons involved in the removal of excessive GABA from the synaptic cleft and the extrasynaptic space. Diseases associated with GAT1 include neurodevelopmental disorders such as schizophrenia and seizure.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: KLH-conjugated C-terminal peptide of mouse SLC6A1.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Avoid boiling lysates before loading to SDS for WB.
RRID: AB_2810801 (BioLegend Cat. No. 867401) AB_2810802 (BioLegend Cat. No. 867402)
Structure: GAT1 is a 599 amino acid protein with predicted and observed molecular mass of ~ 67 kD.
Distribution: Tissue Distribution: Brain Cellular Distribution: Plasma membrane
Function: GAT1 is a GABA transporter protein that removes excessive GABA from the synaptic cleft and the extrasynaptic space.
Interaction: MPP5, STX1A
Ligand/Receptor: GABA
Cell Type: Astrocytes, GABAergic Neurons, Mature Neurons, Neurons, Oligodendrocytes
Biology Area: Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family: Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
Antigen References: Zafar S, et al. 2018. Front Chem. 6:397. Lie MEK, et al. 2017. Adv. Neurobiol. 16:137-167. Zhou Y, Danbolt NC. 2013. Front Endocrinol (Lausanne). 4:165.
Gene ID: 652923233379212
UniProt: View information about SLC6A1 on UniProt.org
Clone: A18095C
Regulatory Status: RUO
Other Names: GAT-1, GABA Transporter
Isotype: Mouse IgG2b, κ