Biolegend, 868002, Purified anti-Ataxin-2 Antibody, 100μg

Ataxin-2 is a polyglutamine protein involved in several biological processes including regulation of mRNA translation. Ataxin-2 contains 2 domains, Sm1 and Sm2, that are implicated in RNA splicing and protein interactions. In the brain, ataxin-2 is expressed in the hypothalamus, the brain region that is responsible for controlling energy balance and metabolism homeostasis. Mutations in ataxin-2 are associated with the development of spinocerebellar ataxia type 2.  Ataxin-2 mutant protein with intermediate-length polyglutamine expansion (27-33 polyQ) modifies TDP-43 toxicity and is associated with an increased risk of developing amyotrophic lateral sclerosis.
100μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human ataxin-2 recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 - 10 µg per ml. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810809 (BioLegend Cat. No. 868001) AB_2810810 (BioLegend Cat. No. 868002)
Structure: Human ataxin-2 is a 1,313 amino acid protein with a predicted molecular mass of 140 kD.
Distribution: Tissue distribution: Brain, spinal cord, heart, liver, skeletal muscle, pancreas, and placenta Cellular distribution: Cytoplasm
Function: Ataxin-2 is involved in the RNA splicing, protein interactions, and metabolic homeostasis.
Interaction: Ataxin-2 interacts with TARDBP, RBFOX1, polyribosomes, SH3GL2, SH3GL3, SH3KBP1, CBL, EGFR, and ATXN2L.
Cell Type: Neurons
Biology Area: Neurodegeneration, Neuroscience, Synaptic Biology
Antigen References: Carmo-Silva S, et al. 2017. Trends Endocrinol Metab. 28(4):309-318. van den Heuvel DM, et al. 2014. Trends Mol Med. 20(1):25-35. Becker LA, et al. 2017. Nature. 544(7650):367-371. Scoles DR, et al. 2017. Nature. 544(7650):362-366
Gene ID: 6311
UniProt: View information about Ataxin-2 on UniProt.org
Clone: A17203C
Regulatory Status: RUO
Other Names: Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATX2, SCA2, TNRC13, SCA2
Isotype: Mouse IgG2b, κ