Biolegend, 908601, Purified anti-CD66C (CEACAM 6) Antibody (Previously Covance catalog# SIG-3750), 100microl

Anti-human CEACAM6 (CEA related cell adhesion molecule 6, non-specific cross reacting antigen (NCA); CD66c) CEACAM6 is a member of the carcinoembryonic antigen (CEA) gene family. Like other members of the CEA family, CEACAM6, consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant like A and B domain. CEACAM6 encodes a glycosyl phosphatidyl inositol (GPI) linked glycoprotein, which has a molecular weight of 90kDa. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes.
100microl
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This antibody was developed against a tumor cell line expressing CEACAM6.
Formulation: Phosphate-buffered solution with BSA + 0.09% NaN3.Previous lots of this product may have been formulated with 0.1% or 0.05% NaN3 instead of 0.09% NaN3. For further information please contact BioLegend Technical Support or Customer Service.
Preparation: The antibody was purified by affinity chromatography.
Concentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: Store between 2°C and 8°C.
Application: IHC-P - Quality tested ICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a dilution of 1:40 is suggested. For immunocytochemistry, a concentration range of 1:100 - 1:200 dilution is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application References(PubMed link indicates BioLegend citation): Hammarstrom S. 1999. Semin Cancer Biol 9:67-81. (EM) Hanenberg H, et al. 1994. Leukemia. 12:2127. (ICC) Daniel S, et al. 1993. Int J Cancer. 55:303. (IHC) Gottlinger HG, et al. 1988. Cancer Res. 48:2198. (ICC)
Product Citations: Wang C, et al. 2023. Immunity. 576:56. PubMed
RRID: AB_2565088 (BioLegend Cat. No. 908601)
Structure: Expected MW: 45 kD
Biology Area: Immunology
Molecular Family: CD Molecules
Gene ID: 4680
UniProt: View information about CD66C on UniProt.org
Clone: 9A6
Regulatory Status: RUO
Other Names: carcinoembryonic antigen-related cell adhesion molecule 6
Previously: Signet Catalog# 750-001Signet Catalog# 750-005Covance Catalog# SIG-3750
Isotype: Mouse IgG1, κ