CST, 31358S, DIMT1 Antibody

Polyclonal Antibody for studying Dimt1. Validated for Western Blotting. Highly specific and rigorously validated in-house, DIMT1 Antibody (CST #31358) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity DIMT1 Antibody recognizes endogenous levels of total DIMT1 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val98 of human DIMT1 protein. Antibodies are purified by peptide affinity chromatography. Background Dimethyladenosine transferase 1 (DIMT1), also known as DIMT1L, is a methyltransferase responsible for the dimethylation of adenosines on the 18S rRNA subunit. Binding of DIMT1 to the pre-rRNA is required for proper processing of the 18S subunit (1). Independent of its catalytic activity, DIMT1 seems to function as a scaffold protein that is essential for the assembly of the 40S rRNA subunit (2). DIMT1 also has been shown to have higher expression in certain cancer types, including multiple myeloma and gastric cancer (3,4). Alternate Names 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; DIM1; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; DIM1 dimethyladenosine transferase 1-like (S. cerevisiae); dimethyladenosine transferase; DIMT1; DIMT1 rRNA methyltransferase and ribosome maturation factor; DIMT1L; HSA9761; HUSSY5; Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; Probable dimethyladenosine transferase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 35 SOURCE: Rabbit