Cytiva, 29719933, Biacore™ 1 series SPR systems

Biacore™ 1K+ Upgrade kit Expand your application range with Cytiva’s Biacore™ 1 series surface plasmon resonance (SPR) platform. Designed for increased assay flexibility, this system features six flow-cells, reducing complexity and deliver robust and reproducible data. All systems are built for analysis in a GxP-regulated environment. • No programming skills needed: Set up and start the analysis with predefined methods. • Flexible software tools: Speed up the assay development and analysis for a wide range of applications. • Straightforward transfer of methods: To other Biacore 1 series or Biacore 8 series systems. • Reduced time to competency: Faster result generation and evaluation. • Simpler data interpretation: Compile, visualize and export data with results in minutes. • Novel injection and running tools: Enable multi-complex applications and improved operational efficiency. • Maximize run efficiency — queue methods or assays and let it run overnight or over the weekend. Compare key features of the three Biacore™ 1 series configurations: This one-needle SPR platform comes in three system configurations, Biacore™ 1K, Biacore™ 1K+ and Biacore™ 1S+, with increasing flexibility in assay design, throughput, capacity and analysis temperature.

	Biacore™ 1K	Biacore™ 1K+	Biacore™ 1S+	Specification description and impact
Dissociation rate	10-6 to 1 s-1	10-6 to 1 s-1	10-6 to 6 s-1	10-6 to 1 s-1 allows you to reliable determine molecules with very fast and slow off-rates.
Affinity range	fM to mM	fM to mM	fM to mM	Exceptional dynamic range allows you to measure abroad range of molecules in pure or crude samples
Short term noise	Typically < 0.03 RU (RMS)	Typically < 0.03 RU (RMS)	Typically < 0.01 RU (RMS)	Value < 0.01 allows you to separate sensorgrams and measure interactions down to milli-resonance unit (mRU), well suited for interactions with really slow off rates.
Analysis temperature	25°C to 37°C	25°C to 37°C	4°C to 40°C	Temperature controlled compartments for samples and analysis, ensure molecule stability and allows you to measure interactions with molecules in native and active stage.
Data collection rate	1 or 10 Hz	1 or 10 Hz	1, 10 or 40 Hz	A data collection rate of 40 Hz increases the resolution of interactions and improves the accuracy of rapid on- and off-rate determinations.
Sample capacity	1 × 96- or 384-well microplate 1 × reagent rack with 21 to 43 positions	2 × 96- or 384-well microplate 2 × reagent rack with 21 to 43 positions	2 × 96- or 384-well microplate 2 × reagent rack with 21 to 43 positions	Increase flexibility in sample capacity and volume, with opportunity to run of up to 768 interactions in one go.
Six flow cells addressing	Individually as single flow cells or pairwise	Individually as single flow cells, pairwise or all flow cells in series.	Individually as single flow cells, pairwise or all flow cells in series.	Six flow cells increase analytical capacity – saving assay time, sample quantity, and sensor chips, and enables multiplexing capability.
Unattended run time	60 h	72 h	72 h	Increase throughput and analytical efficiency with method queueing capabilities with a minimum of manual intervention.

Biacore™ Insight software Biacore™ Insight software offers unified instrument control and data evaluation, allowing straightforward transfer of methods to Biacore™ 1 series and Biacore™ 8 series SPR systems. Enhance functionality with optional application-specific software extensions and machine learning-based evaluation tools, reducing your time to results.

Visit the Biacore™ Insight software product page here . Biacore™ Consumables Cytiva provides a range of tools to ensure reliable and reproducible data with minimal effort:
• Series S sensor chips : All sensor chips are produced in an quality-controlled environment. Compatible with Biacore™ SPR systems, these sensor chips support analysis of interactions from small organic molecules to viruses. • Kits, buffers, and reagents : Reduce assay development time with consistent capture of antibodies and molecules via common tags. Ready-made buffers and solutions ensure reliable results and ease of use. Predefined Methods Biacore™ Insight control software includes predefined methods with application-relevant settings for major assays. Start experiments in minutes using these methods and Biacore™ SPR consumables. What’s included Biacore™ 1 series system packages include the instrument and 2 licenses of Biacore™ Insight Software (product code 29310602).