Cytiva, ILOS030T120407, Cadence™ inline concentrator modules

Cadence Inline Concentrator Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.7 m² effective filtration area (EFA) Cadence™ inline concentrator, part of our Pall filtration portfolio, allows direct flow-through in-process volume reduction and can be implemented into a process system or operated as a stand alone unit. Similar to other Cadence SPTFF devices, the Cadence ILC utilizes standard Pall T-Series cassettes as the building blocks for the module. These modules are offered with either Delta regenerated cellulose or Omega™ polyethersulfone (PES) 10 kDa or 30 kDa membranes providing the high flux, high selectivity and low protein binding characteristics associated with these membranes. They are available in a range of size formats to accommodate various processing volumes. These products utilize proprietary technology, as well as technology licensed from SPF Innovations, and may be covered by one or more patents. See pall.com/patents. Optimize Economic and Operational Benefits Enhance downstream processing to increase capacity and reduce costs Cadence ILC modules can help to eliminate or reduce the size of intermediate storage tanks and associated cleaning of tanks when used for in-process volume reduction before or after existing steps. Enable in-process volume reduction Depending on the initial concentration and product characteristics, a volume reduction of 2 to 4X (or higher) can be achieved with minimal instrumentation or system requirements. Optimize processing of highly shear-sensitive products Processing with the Cadence ILC results in only one pass through the pump and module, reducing shear exposure. For products sensitive to pumping, the pump can be completely eliminated by using pressurized vessels to flow the process fluid through the module. Further benefits are achieved by eliminating any mixing or foaming issues associated with the feed tank. No holder required Cadence ILC modules are provided assembled, and the cassettes and manifolds are pre-torqued between two end plates so that no extra holder is required. Benefits include: Easy connection to a pressure source, like a pump or pressure vessel
Simplified in-process volume reduction
Continuous processing enabled by process coupling
The module feed, retentate and permeate ports are easily connected to the appropriate outlets using clearly marked ports Product Platform Innovative SPTFF processing takes place within the Cadence ILC modules. The modules incorporate Pall’s proven T-series cassettes with Delta or Omega™ membrane and are available in different formats to accommodate various processing volumes (see ordering information). Applications The Cadence ILC is designed for continuous processing or for in-process volume reduction in various steps in a wide range of applications in the biopharmaceutical industry. These include recovery of antibodies or recombinant proteins, and preparation of samples (concentrating, desalting) before or after column chromatography, and can be implemented in existing facilities facing tank capacity issues or to other process optimization opportunities.