Proteintech, 13138-1-AP, CCNL1 Polyclonal antibody

Size: 20ul / 150ul The CCNL1 (13138-1-AP) by Proteintech is a Polyclonal antibody targeting CCNL1 in WB, ELISA applications with reactivity to human, mouse, rat samples 13138-1-AP targets CCNL1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: COLO 320 cells, MCF-7 cells, PC-3 cells, MDA-MB-231 cells Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information CCNL1, also named as Cyclin-L1, contains a RS region and belongs to the cyclin family. CCNL1 localizes in the nucleus speckle and is Overexpressed in primary tumors of head and neck squamous cell carcinomas (HNSCC). CCNL1 as transcriptional regulator participates in regulating the pre-mRNA splicing process. It is seems to be involved in the regulation of RNA polymerase II (pol II). CCNL1 functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. It may be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). The calculated molecular weight of CCNL1 is about 55-60 kDa, but we detected a 40-50 kDa isoform by western blotting. Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag3731 Product name: Recombinant human CCNL1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 227-526 aa of BC007081 Sequence: YMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR Predict reactive species Full Name: cyclin L1 Calculated Molecular Weight: 526 aa, 60 kDa Observed Molecular Weight: 46 kDa GenBank Accession Number: BC007081 Gene Symbol: CCNL1 Gene ID (NCBI): 57018 RRID: AB_10640299 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9UK58 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.