Proteintech, 16168-1-AP, PSEN2-Specific Polyclonal antibody

Size: 20ul / 150ul The PSEN2-Specific (16168-1-AP) by Proteintech is a Polyclonal antibody targeting PSEN2-Specific in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples 16168-1-AP targets PSEN2-Specific in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: C6 cells, A549 cells, NIH/3T3 cells Positive IHC detected in: human kidney tissue, human placenta tissue, human colon tissue, mouse brain tissue, human breast cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Recommended dilution Western Blot (WB): WB : 1:300-1:800 Immunohistochemistry (IHC): IHC : 1:20-1:200 Background Information Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1. Specification Tested Reactivity: human, mouse, rat Cited Reactivity: mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: presenilin 2 (Alzheimer disease 4) Calculated Molecular Weight: 50 kDa Observed Molecular Weight: 55-60 kDa GenBank Accession Number: NM_000447 Gene Symbol: PSEN2 Gene ID (NCBI): 5664 RRID: AB_2170748 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P49810 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.