Proteintech, 16362-1-AP, TMEM43 Polyclonal antibody

Size: 20ul / 150ul The TMEM43 (16362-1-AP) by Proteintech is a Polyclonal antibody targeting TMEM43 in IHC, ELISA applications with reactivity to human, mouse, rat samples 16362-1-AP targets TMEM43 in IHC, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive IHC detected in: mouse heart tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Recommended dilution Immunohistochemistry (IHC): IHC : 1:50-1:500 Background Information Transmembrane protein 43 (TMEM43), a member of the TMEM subfamily, is encoded by a highly conserved gene and is widely expressed in most species, ranging from bacteria to humans. The TMEM43 S358L mutation on chromosome 3p25 is an important cause of arrhythmogenic right ventricular cardiomyopathy (ARVC) as it enhances the NF-κB-TGFβ signal cascade, which can lead to aggressive disease at the early stage, and might later develop into heart disease. (PMID: 35260078) Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag8522 Product name: Recombinant human TMEM43 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-314 aa of BC008054 Sequence: RLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE Predict reactive species Full Name: transmembrane protein 43 Calculated Molecular Weight: 400 aa, 45 kDa GenBank Accession Number: BC008054 Gene Symbol: TMEM43 Gene ID (NCBI): 79188 RRID: AB_3085488 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9BTV4 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.