Proteintech, 17001-1-AP, METTL7B Polyclonal antibody

Size: 20ul / 150ul The METTL7B (17001-1-AP) by Proteintech is a Polyclonal antibody targeting METTL7B in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples 17001-1-AP targets METTL7B in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: mouse liver tissue, rat liver tissue Positive IHC detected in: mouse liver tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Immunohistochemistry (IHC): IHC : 1:50-1:500 Background Information METTL7B is a membrane-associated small-molecule methyltransferase that catalyzes S-methylation of alkyl thiols, thereby linking thiol/sulfur metabolism, redox homeostasis, and cellular stress responses. By influencing antioxidant enzyme expression and detoxification pathways, METTL7B plays a pivotal role in tumor growth and drug resistance, particularly in lung adenocarcinoma. Its upregulation in multiple cancers and involvement in redox/thiol metabolism make it an emerging therapeutic target in oncology and possibly in metabolic/oxidative stress-related disease settings. (PMID: 40068772) Specification Tested Reactivity: human, mouse, rat Cited Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag10694 Product name: Recombinant human METTL7B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 39-244 aa of BC020509 Sequence: MAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK Predict reactive species Full Name: methyltransferase like 7B Calculated Molecular Weight: 244aa,28 kDa Observed Molecular Weight: 28 kDa GenBank Accession Number: BC020509 Gene Symbol: METTL7B Gene ID (NCBI): 196410 RRID: AB_2142199 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q6UX53 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.