Proteintech, 18797-1-AP, HSF4 Polyclonal antibody

Size: 20ul / 150ul The HSF4 (18797-1-AP) by Proteintech is a Polyclonal antibody targeting HSF4 in WB, ELISA applications with reactivity to human, mouse samples 18797-1-AP targets HSF4 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: HeLa cells, mouse skeletal muscle tissue, human skeletal muscle tissue, human heart tissue, MCF-7 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information HSF4 belongs to the HSF family. HSF4 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE). The isoform HSF4A represses transcription while the isoform HSF4B activates transcription. HSF4 is a homotrimer which exhibits constitutive DNA binding and forms trimers even in the absence of stress. It is expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. Mutation of HSF4 will cause lamellar cataract which is known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds. Inheritance of these forms of cataract is autosomal dominant. Specification Tested Reactivity: human, mouse Cited Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: heat shock transcription factor 4 Calculated Molecular Weight: 53 kDa Observed Molecular Weight: 53-58 kDa GenBank Accession Number: BC130383 Gene Symbol: HSF4 Gene ID (NCBI): 3299 RRID: AB_10598014 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9ULV5 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.