Proteintech, 27863-1-AP, C1orf112 Polyclonal antibody

Size: 20ul / 150ul The C1orf112 (27863-1-AP) by Proteintech is a Polyclonal antibody targeting C1orf112 in WB, ELISA applications with reactivity to human samples 27863-1-AP targets C1orf112 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: A431 cells, HEK-293 cells, K-562 cells, SH-SY5Y cells, SK-N-SH cells Recommended dilution Western Blot (WB): WB : 1:1000-1:8000 Background Information FIRRM (Fanconi anemia pathway and RAD51-mediated DNA repair regulator, also known as C1orf112 or FLIP) is an evolutionarily conserved protein involved in DNA damage repair and homologous recombination. It ensures DNA cross-link (ICL) repair and genomic stability by regulating RAD51 activity. FIRRM expression is upregulated in a variety of tumors and correlates with poor prognosis. Its dysfunction leads to increased genomic instability, as evidenced by enhanced DNA damage signaling, chromosomal abnormalities, and micronucleus formation. The study of FIRRM is important for understanding the mechanisms of tumorigenesis and developing new therapeutic strategies. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag27316 Product name: Recombinant human C1orf112 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 361-530 aa of BC107168 Sequence: AIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG Predict reactive species Full Name: chromosome 1 open reading frame 112 Calculated Molecular Weight: 853 aa, 97 kDa Observed Molecular Weight: 98 kDa GenBank Accession Number: BC107168 Gene Symbol: C1orf112 Gene ID (NCBI): 55732 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9NSG2 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.