Proteintech, 28607-1-AP, DYRK1A Polyclonal antibody

Size: 20ul / 150ul The DYRK1A (28607-1-AP) by Proteintech is a Polyclonal antibody targeting DYRK1A in WB, ELISA applications with reactivity to human samples 28607-1-AP targets DYRK1A in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: DU 145 cells, HEK-293 cells, LNCaP cells, PC-3 cells Recommended dilution Western Blot (WB): WB : 1:2000-1:12000 Background Information This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag29433 Product name: Recombinant human DYRK1A protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 525-763 aa of NM_001396 Sequence: GRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS Predict reactive species Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Calculated Molecular Weight: 86 kDa Observed Molecular Weight: 70kDa, 85 kDa GenBank Accession Number: NM_001396 Gene Symbol: DYRK1A Gene ID (NCBI): 1859 RRID: AB_3086069 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q13627 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.