Proteintech, 28791-1-AP, Phospho-XIAP (Ser87) Polyclonal antibody

Size: 20ul / 100ul The Phospho-XIAP (Ser87) (28791-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-XIAP (Ser87) in WB, ELISA applications with reactivity to Human, mouse, rat samples 28791-1-AP targets Phospho-XIAP (Ser87) in WB, ELISA applications and shows reactivity with Human, mouse, rat samples. Tested Applications Positive WB detected in: PDGF treated NIH/3T3 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:6000 Background Information XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. XIAP is directly phosphorylated by PKC and that XIAP phosphorylated at Ser87 by PKC is resistant to degradation, protecting cells from apoptosis-inducing stress. Specification Tested Reactivity: Human, mouse, rat Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: X-linked inhibitor of apoptosis Calculated Molecular Weight: 60 kDa Observed Molecular Weight: 57 kDa GenBank Accession Number: BC032729 Gene Symbol: XIAP Gene ID (NCBI): 331 RRID: AB_2881213 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P98170 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.