Proteintech, 28875-1-AP, Phospho-GSK3A (Ser21) Polyclonal antibody

Size: 20ul / 100ul The Phospho-GSK3A (Ser21) (28875-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-GSK3A (Ser21) in WB, ELISA applications with reactivity to Human samples 28875-1-AP targets Phospho-GSK3A (Ser21) in WB, ELISA applications and shows reactivity with Human samples. Tested Applications Positive WB detected in: Calyculin A treated PC-3 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:6000 Background Information GSK3A (glycogen synthase kinase 3 alpha), one of the two functional isoforms encoded by the GSK3 gene, is a serine/threonine protein kinase that is involved in cell-cycle progression, differentiation, and apoptosis (PMID: 27049759). Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin.GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3A and Ser9 of GSK-3B. GSK3A acts as a tumor suppressor and has important roles in acute myeloid leukemia (AML), prostate cancer, and pancreatic cancer (PMID: 22326953, 22539113, 23547054). Specification Tested Reactivity: Human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: glycogen synthase kinase 3 alpha Calculated Molecular Weight: 483 aa, 51 kDa Observed Molecular Weight: 51 kDa GenBank Accession Number: BC027984 Gene Symbol: GSK3A Gene ID (NCBI): 2931 RRID: AB_2918211 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P49840 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.