Proteintech, 29568-1-AP, Phospho-PLCG2 (Tyr1217) Polyclonal antibody

Size: 20ul / 100ul The Phospho-PLCG2 (Tyr1217) (29568-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-PLCG2 (Tyr1217) in WB, ELISA applications with reactivity to Human samples 29568-1-AP targets Phospho-PLCG2 (Tyr1217) in WB, ELISA applications and shows reactivity with Human samples. Tested Applications Positive WB detected in: pervanadate treated Raji cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information Phospholipase C gamma 2 (PLCG2) belongs to the family of phospholipase C-gamma, which is the downstream molecule of the CSF1R. Previous studies have demonstrated that PLCG2 was required for CSF1-induced differentiation of monocytes, microglia, immune, inflammatory responses. PLCG2 phosphorylation leads to an increase in production of the cellular signaling molecules, diacylglycerol (DAG), and inositol 1,4,5 trisphosphate (IP3), which further promotes a wide range of downstream signals, including the phosphorylation of protein kinase C (PKC) family members, such as PKC epsilon (PKCε). (PMID: 32522286) Specification Tested Reactivity: Human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: phospholipase C, gamma 2 (phosphatidylinositol-specific) Calculated Molecular Weight: 148 kDa Observed Molecular Weight: 148-150 kDa GenBank Accession Number: BC007565 Gene Symbol: PLCG2 Gene ID (NCBI): 5336 RRID: AB_3669689 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P16885 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.