Proteintech, 30895-1-AP, Phospho-TAK1 (Ser439) Polyclonal antibody

Size: 20ul / 100ul The Phospho-TAK1 (Ser439) (30895-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-TAK1 (Ser439) in WB, ELISA applications with reactivity to human samples 30895-1-AP targets Phospho-TAK1 (Ser439) in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HEK-293T cells, λ phosphatase treated HEK-293T cells Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information MAP3K7(Mitogen-activated protein kinase kinase kinase 7) is also named as TAK1 and belongs to the MAP kinase kinase kinase subfamily. TAK1 has been identified as a crucial regulatory component of MAPK and nuclear factor-κB (NF-κB) signaling pathways, which play a key role in lipid metabolism and inflammation. Activated TAK1 then phosphorylates downstream substrates to spark the NF-κB and MAPK signaling pathways. Hence, phospho-TAK1 confers most of its regulatory functions, and inhibiting the hyperactivation of TAK1 should be a promising NASH(Nonalcoholic steatohepatitis ) therapy. (PMID: 34146477) This antibody is equivalent to Ser412 in mice. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: mitogen-activated protein kinase kinase kinase 7 Calculated Molecular Weight: 579 aa, 64 kDa Observed Molecular Weight: 75-85 kDa GenBank Accession Number: BC017715 Gene Symbol: TAK1 Gene ID (NCBI): 6885 RRID: AB_3669777 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: O43318 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.