Proteintech, 31488-1-AP, TMCO3 Polyclonal antibody

Size: 20ul / 150ul The TMCO3 (31488-1-AP) by Proteintech is a Polyclonal antibody targeting TMCO3 in IP, ELISA applications with reactivity to human samples 31488-1-AP targets TMCO3 in IP, ELISA applications and shows reactivity with human samples. Tested Applications Positive IP detected in: HepG2 cells, HuH-7 cells Recommended dilution Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate Background Information TMCO3, also known as transmembrane and coiled-coil domains 3 or C13orf11, is a protein-coding gene with functional annotation of probable Na+/H+ antiporter. It belongs to the monovalent cation:proton antiporter-2 (CPA2) family according to the Transporter Classification Database (TCDB) (PMID: 33170213). Most CPA2 family members have similar functions and are involved in ion transport (K+, Na+, and H+) in bacteria, archaea, insects, and plants. Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC, providing a potential therapeutic target for HCC treatment (PMID: 36304514). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag35012 Product name: Recombinant human TMCO3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 23-285 aa of BC068515 Sequence: VEHEEVAQRVIKLHRGRGVAAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDVGLSDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVKGVNFEAVLRVEEEEANSKQNITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCG Predict reactive species Full Name: transmembrane and coiled-coil domains 3 Calculated Molecular Weight: 75 kDa Observed Molecular Weight: 70 kDa GenBank Accession Number: BC068515 Gene Symbol: TMCO3 Gene ID (NCBI): 55002 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity Purification UNIPROT ID: Q6UWJ1 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.