Proteintech, 33963-1-AP, CENPS-CORT Polyclonal antibody

Size: 20ul / 150ul The CENPS-CORT (33963-1-AP) by Proteintech is a Polyclonal antibody targeting CENPS-CORT in WB, ELISA applications with reactivity to human samples 33963-1-AP targets CENPS-CORT in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: Jurkat cells, K-562 cells, THP-1 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information CENPS-CORT is a centromeric protein complex composed of core subunits such as CENPS and CENPT, playing a critical role in chromosome biology. This complex localizes to the centromere region and directly participates in the assembly and maintenance of the centromere-kinetochore structure, ensuring accurate chromosome segregation during both mitosis and meiosis. Its functions primarily include promoting nucleosome assembly at the centromere, maintaining the three-dimensional structural integrity of the centromere, and ensuring the fidelity of chromosome separation by regulating microtubule-kinetochore attachments. Studies have shown that dysfunction of the CENPS-CORT complex disrupts the accuracy of chromosome segregation, leading to chromosomal numerical abnormalities such as aneuploidy, which is closely associated with tumorigenesis and reproductive disorders. It is therefore an important subject in research on cell cycle regulation and genomic stability. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag40952 Product name: Recombinant human CENPS-CORT protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-138 aa of Sequence: MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN Predict reactive species Full Name: CENPS-CORT readthrough Calculated Molecular Weight: 15kDa Observed Molecular Weight: 19 kDa Gene Symbol: CENPS-CORT Gene ID (NCBI): 100526739 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity Purification UNIPROT ID: Q8N2Z9 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.